Physionic

Are you tired of this, too?

Are you tired of listening to health podcasts and not knowing if the guest is talking real data driven perspective or if they're pulling BS out of their rear-end?

I am. I've stopped listening to podcasts, because I'm getting frustrated listening. Or, at least, I stopped listening until now...

I'm starting a new show on the channel - it's called 'The Centrifuge', where we spin out the BS from the science (lab nerds will especially appreciate the name, I think). Essentially, I'm going to go through the majority of popular podcast episodes (Attia, Huberman, Jay Shetty, Mel Robbins, you name it), and across multiple episodes, I will dissect the claims - both wild and fair - and add scientific references, context, and application to the words uttered. No more guesswork.

The episodes will *not* interfere or replace any of the other original videos I release - they are 'in addition to' the regular scheduled programming. This is a trial run, but I feel passionate about this, because: I'm tired of the pseudoscientific BS. So, we'll see if it sticks around (it takes me weeks of work for each podcast episode), but I do think it'll help you identify what claims have at least some scientific basis and which do not.

I've recorded 3 episodes already - the first episode releases THIS SATURDAY (12/13) and begins with a two part on a prominent doctor. I'm excited - I hope it helps!

(Also, tomorrow's video is going to be a sweet one... pun intended.)

Nic

6 days ago | [YT] | 1,435

Physionic

Hey all, I was interviewed/had a wonderful discussion with Dr. Nick Norwitz over on his channel on two topics you might find interesting - especially the seed oil discussion, but if you've seen my recent coverage on FGF21, you'll prefer the 'Sugar Diet' video. Both are linked below.

Seed Oils: https://youtu.be/VDJGCw-enhI?si=27ooU...

'Sugar Diet': https://youtu.be/YPGBQPqvwDg?si=ODtFz...

Hope you enjoy!

4 months ago | [YT] | 284

Physionic

Hi all - I unlisted my LMHR video, because I received some excellent critiques and was made aware of some additional information I wasn't aware of during the first recording. So, I'm going to address those critiques and upload a new video, but I'll include the original video in the description of the new video for those that still want to see what I originally said.

I appreciate the respectful, critical feedback, as always.

8 months ago | [YT] | 1,382

Physionic

After much deliberation with family and friends, I have made the difficult decision...

...to wear a belt.

IYKYK. 😉

9 months ago | [YT] | 441

Physionic

Hi all - I'm doing a promised live session with the Physionic Community this Saturday. I'll be covering my personal research and just generally hanging out. It's free, but you must be part of the free Physionic Community (bit.ly/PhysionicCommunity2) or on the email list (bit.ly/2AXIzK6) to join.

Neither the live session nor the recording will be on YouTube, so be sure to join via either method above, if you can!

Should be a fun time - hope you can make it,
Nic

11 months ago | [YT] | 169

Physionic

C15 Fats. I had to break it into 2 videos, because I had a lot to say. Releases next week (barring any complications with editing).

For reference, I started reading the studies on the topic over 2 weeks ago - it takes a long time to make sure the information is accurate and fair, but I'm very much looking forward to discussing with you - these were fun videos...

See you on Monday (and have a great weekend!),
Nic

1 year ago | [YT] | 752

Physionic

Hi all - I've looked over the literature for studies on canola oil and inflammation (in humans) and found 8 studies (see below). I'm wondering, since seed oils and canola oil are such polarizing topics and *surely* people have presented evidence for their stances, if you know of any other studies (in humans) that look at canola oil/rapeseed oil and inflammation (pro-inflammatory, anti-inflammatory, etc.) that I have missed, could you post them below?

I'd like to review all the studies I can so it doesn't seem like I'm cherry picking. Please post any below - they can be associative, but preferably RCTs (in humans).

Studies I have already:
1. Nikooyeh B, Zargaraan A, Ebrahimof S, et al. Daily consumption of γ-oryzanol-fortified canola oil, compared with unfortified canola and sunflower oils, resulted in a better improvement of certain cardiometabolic biomarkers of adult subjects with type 2 diabetes: a randomized controlled clinical trial. Eur J Med Res. 2023;28(1):416. Published 2023 Oct 10. doi:10.1186/s40001-023-01409-8

2. Morvaridi M, Jafarirad S, Seyedian SS, Alavinejad P, Cheraghian B. The effects of extra virgin olive oil and canola oil on inflammatory markers and gastrointestinal symptoms in patients with ulcerative colitis. Eur J Clin Nutr. 2020;74(6):891-899. doi:10.1038/s41430-019-0549-z

3. Khandouzi N, Zahedmehr A, Nasrollahzadeh J. Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred for coronary angiography. Lipids Health Dis. 2020;19(1):183. Published 2020 Aug 14. doi:10.1186/s12944-020-01362-z

4. Atefi M, Pishdad GR, Faghih S. The effects of canola and olive oils on insulin resistance, inflammation and oxidative stress in women with type 2 diabetes: a randomized and controlled trial. J Diabetes Metab Disord. 2018;17(2):85-91. Published 2018 May 23. doi:10.1007/s40200-018-0343-9

5. Manning PJ, Sutherland WH, McGrath MM, de Jong SA, Walker RJ, Williams MJ. Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity (Silver Spring). 2008;16(9):2046-2052. doi:10.1038/oby.2008.334

6. Gillingham LG, Gustafson JA, Han SY, Jassal DS, Jones PJ. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr. 2011;105(3):417-427. doi:10.1017/S0007114510003697

7. Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity (Silver Spring). 2016;24(11):2261-2268. doi:10.1002/oby.21584

8. Perez-Herrera A, Delgado-Lista J, Torres-Sanchez LA, et al. The postprandial inflammatory response after ingestion of heated oils in obese persons is reduced by the presence of phenol compounds. Mol Nutr Food Res. 2012;56(3):510-514. doi:10.1002/mnfr.201100533

(Human studies only, did I mention that already? :) )

Thanks!

1 year ago (edited) | [YT] | 862

Physionic

Video take-down:
Study Analysis: GLP-1RAs on Weight Loss

Hello - If you aren't aware, under all my videos I have a 'Critique my Work' link so people can point out where I've made mistakes. Recently, someone (Dr. Mills) wrote in that one of the meta-analyses I covered in my GLP1RA study analysis had far more flaws in it than I presented. After a lengthy discussion with them, it seemed clear that the meta-analysis had more flaws in it than justifiable for a simple 'Amendment' under the video. As such, I've taken the video down.

Ultimately, the conclusion of the video likely stands (i.e. GLP1RAs cause weight loss), even in the face of this poor data, but it's still better to take down the video than keep it up with the assumption the data presented was high quality (because the end result isn't all that matters - learning how we get to that conclusion is also extremely valuable). Anyway, I'm thrilled to have had the opportunity to learn from an expert in meta-analysis like Dr. Mills, and expect to continue to improve to make sure I don't miss any other flaws in these types of studies.

Anyway, thank you to Dr. Kerry Mills for the corrections, and I hope you all have a great day.

Nic

1 year ago | [YT] | 1,249

Physionic

I get this question a lot - first off, I'm thankful anyone even gives a hoot what I have to say on the matter. Secondly, I'm working on it - I've pulled together 7 studies on the topic, and I'll do one more search to make sure I don't miss any others. It'll likely take me a few weeks to get through it all, but certainly expect me to cover it.

Looking forward to it,
Nic

1 year ago | [YT] | 1,106

Physionic

SEED OILS

I'm slowly turning my attention to covering how seed oils affect our health. As I'm a one man band and I have limited time, I'm asking you to choose the top two seed oils you've heard are the most destructive to our health. I'm happy to revisit the topic if people end up interested in wanting more, but for now, let's stick to the top two. I'm also working on other content that is not seed oil related (seedless content?).

I will be releasing another poll soon on the outcomes of interest (inflammation, heart disease, cancer, etc.) since they don't fit on this poll.

I added just these 4, because I can only poll 4 and these seem to get brought up a lot.

Thanks,
Nic

1 year ago | [YT] | 520