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Ben Greenfield Life
This woman lived to 117: here’s what her genes and lifestyle tell us about longevity - www.nature.com/articles/d41586-025-03112-6
Want to know the quick details? Keep reading.
Scientists studied Maria Branyas, the world’s oldest person, using multi-omics (genomics, proteomics, etc.) to map her biology. Spoiler: It’s a mix of good genes and body hacks fighting aging. 🧬👵
Methods: They analyzed blood samples for DNA, proteins, metabolism, gut bacteria, and more—without invasive tests. Compared her to typical 100-year-olds and younger folks. This is the deepest dive into a supercentenarian yet. 🔬
Aging signs were there: Super short telomeres (like frayed chromosome ends), mutations in blood cells (clonal hematopoiesis), and more age-related B cells in her immune system. Her body showed extreme age—but handled it like a boss. ⏳
Protective genes: Rare variants that shield the heart and brain from damage. Think built-in armor against heart disease and neurodegeneration. These aren’t common, but they might explain why she dodged major illnesses. ❤️🧠
Metabolism win: Active lipid (fat) processing kept things balanced. No high cholesterol or diabetes markers—her body efficiently managed energy, avoiding common old-age pitfalls. ⚡
Low inflammation: Unlike most elderly, her inflammation levels were chill, reducing wear and tear on organs. Plus, an efficient immune response that fought threats without overreacting. 🛡️
Gut health bonus: A “rejuvenated” microbiome full of beneficial bacteria like bifidobacteria, similar to younger people. This supports digestion, immunity, and overall vibe - and she ate Mediterranean-style foods: olive oil, fish, and 3 servings of plain yogurt daily. 🦠
Epigenetic youth: Her “epigenetic clocks” (DNA markers of biological age) ticked slower—she was epigenetically younger than her 117 years. This deceleration might be key to her extra decades. 🕰️
Big picture: No magic pill, but this shows longevity comes from genes, low inflammation, strong immunity, and a young-like biology. Could inspire treatments for aging diseases.
1 day ago | [YT] | 18
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Ben Greenfield Life
Back when I used to race Ironman, I tried this theory about honey being just as good as an energy gel, but good luck sucking down honey during a long endurance workout without a mess: pubmed.ncbi.nlm.nih.gov/40675563
2 days ago | [YT] | 6
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Ben Greenfield Life
Yes, I know genetics dictate different people respond differently to weed’s effects on the brain, but this meta-analysis of 23 observational studies in 1,490 participants showed FREQUENT use of cannabis (0.5 to 2.8 grams per day) is associated with small to moderate deficits in cognitive function in 10 out of 13 areas of thinking: pubmed.ncbi.nlm.nih.gov/40675034
3 days ago | [YT] | 6
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Ben Greenfield Life
Cancer treatment protocol with what appears to be impressive results -
www.zerohedge.com/medical/keto-ivermectin-fenbenda…
4 days ago | [YT] | 18
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Ben Greenfield Life
What NON DRUG therapies work best for serious gut issues? This meta-analysis of 62 randomized controlled trials reported that acupuncture, fecal transplant, and diet helped treat inflammatory bowel disease (IBD) the best: pubmed.ncbi.nlm.nih.gov/40662074
5 days ago | [YT] | 16
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Ben Greenfield Life
When it comes to sitting and accelerated aging markers in women:
- 42% worse when sitting for 4 to 6 hours per day
- 67% worse when sitting for 6 to 8 hours per day
- 107% worse when sitting for 8 or more hours per day
pubmed.ncbi.nlm.nih.gov/40610691
1 week ago (edited) | [YT] | 11
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Ben Greenfield Life
Well, “wonder drug“ (as titled in this article) might be a bit clickbaity, but I certainly take ivermectin (combined with antifungal fenbezadole) when I travel, as immune insurance: pmc.ncbi.nlm.nih.gov/articles/PMC3043740/ (I get my combo from Mitozen: www.mitozen.com/bgl/, code BEN)
1 week ago | [YT] | 11
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Ben Greenfield Life
No, you’re not going to lose a bunch of muscle with occasional long-term fasts… (In this case, up to 12 days!): onlinelibrary.wiley.com/doi/10.1002/jcsm.13773
2 weeks ago | [YT] | 16
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Ben Greenfield Life
Probably not super surprising to hear, but when it comes to BONE DENSITY, weight training with low reps/high intensity beats high reps/low weight: pubmed.ncbi.nlm.nih.gov/40409129
2 weeks ago | [YT] | 23
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Ben Greenfield Life
Yes, the latest science shows sunscreen can block vitamin D production: pubmed.ncbi.nlm.nih.gov/40246233
I personally use sunscreen on my face if I’m going to be out in the sun for longer than about 45 minutes, and on my entire body if I risk burning, but it’s important to know the effects on vitamin D production!
2 weeks ago | [YT] | 12
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