Bryan Johnson

22 hours ago | [YT] | 2,702

Bryan Johnson

I’ve maintained a 85% reduction in microplastics in my blood for six months now, putting me in the lowest 8.12% of people for microplastic contamination.

My blood microplastics results:
Oct 2024: 70 particles/mL
May 2025: 10 particles/mL
Nov 2025: 10 particles/mL

The intervention we think most contributes to my drop in blood microplastics is daily dry sauna (200°F, 20 min, ice pack on boys), which also helped clear many other environmental toxins, including several plastic-related chemicals.

Additionally, I have tried to reduce exposure generally:
+ no microwaving in plastic
+ no plastic cutting boards
+ reverse osmosis water filter at home
+ generally minimizing plastic contact with food, drink, and heat
+ removal of synthetic fibers
+ MERV 13 filter

To our knowledge, this is one of the first longitudinal, N=1 datasets showing a large and sustained reduction in blood microplastic burden alongside structured detox and exposure reduction efforts.

Early evidence suggests microplastics can impair male reproductive health. My data suggest that at least part of that burden may be reversible when you aggressively lower exposure and support clearance.

23 hours ago | [YT] | 1,109

Bryan Johnson

human civilization is entering a phase transition where its inherited moral, cognitive, and biological architectures no longer stabilize reality. survival now requires a new integrative ethic oriented around continuity of existence across human, machine, and planetary scales.

1 day ago | [YT] | 1,698

Bryan Johnson

My magic mushroom longevity experiment found a metabolic reset button in the brain. We expected brain changes, but not a potential metabolic breakthrough.

The discovery: my blood glucose control dramatically improved.

+ before: top 2% of population
+ after: top 0.2% of population
+ better than 99.75% of 18-25 yr olds
+ mean glucose dropped 8%
+ time above 125 mg/dL: zero min
+ variability dropped 11%

This single session reduced my estimated HbA1c by 6.8% from 4.7% to 4.4%.

Why does this matter? We treat diabetes and metabolic dysfunction with chronic daily medication (Metformin, Insulin, GLP-1s). This data suggests that a neuroplastic event might have downstream effects on the liver and pancreas that mimic or exceed these drugs.

For context, taking Metformin daily takes 6 months to drop it 10-15%.

This is a first in-human observation, with comparable pre-clinical evidence existing only in rodents.

1 day ago | [YT] | 2,599

Bryan Johnson

You want to prioritize sleep because sleep gives you willpower. You want willpower so that you won't eat fast food. You don't want to eat fast food bc it makes you fat. You don't want to be fat because you feel like shit. Prioritize sleep.

1 day ago | [YT] | 7,798

Bryan Johnson

I’m going to try and achieve immortality by 2039.

One year of time passes and I remain the same biological age.

I invite you to join me.

The search for the fountain of youth is the oldest story ever told. It’s been the dream of dreamers for millennia but always painfully out of reach.

For the first time in the history of life on earth, in just the past 24 months, the window has opened for a conscious being to realistically strive for this goal. It is an absolutely insane moment.

We currently do not know how 2039 immortality will be achieved. There are new, promising therapies that can turn back the clock decades, but they’re buggy. Sometimes they mistakenly cause cancer. We gotta fix that.

But we know immortality is possible because nature has already solved it. This isn’t a physics problem like trying to travel faster than the speed of light, it’s a biological engineering problem that evolution has cracked multiple times.

The freshwater hydra constantly regenerates its own cells and doesn’t succumb to senescence. It is effectively ageless. The "immortal jellyfish" (Turritopsis dohrnii) can revert its cells back to a youthful state and restart its life cycle indefinitely. Lobsters produce an especially active form of an enzyme called telomerase that preserves their telomeres and keeps their DNA from degrading as they age. We need to port the software to humans.

2039 is a reasonable target because of the accelerated, AI-driven rate of innovation. AI is morphing from assistant to scientist. It is powering current researchers with previously unimagined capabilities to enhance discovery and development.

That, coupled with enhanced biomarker measurement, creates a closed-loop system of improvement that will speed things up dramatically.

This is what I’ve been doing for six years. As crude as longevity technology is today, the improvements I’ve personally seen are stunning.

I started as a worn-down, inflamed, aged 42 year old who’d broken himself on the rocks of American food slop and entrepreneurship martyrdom. Six years later, my body largely operates at elite 18 year old levels. That includes my cardiovascular system, fertility, strength, and hormones.

Not all is well though. I have mild to moderate hearing loss in my left ear that we can’t fix and my brain is anatomically age 42 (I’m 48).

Still, unreal results.

My team and I did this by following the scientific method. We measured the biological age of every organ. We referenced the best scientific evidence on how to slow aging and rejuvenate. We methodically completed these protocols and measured again. Rinse and repeat.

We could do so much more and faster if we had better measurement and better therapies. Both of which are cooking all over the world right now.

To speed things up now, I’m currently having thousands of Bryan Johnson organ clones built in a dish. This will allow me to test drugs and other molecules against my biology to accelerate learning and save my body from potential mishaps.

Yes, we’ll make mistakes. Hopefully they won’t be fatal. And of course there’s always bad luck to contend with. But I trust in fate and I believe that destiny is going to grant the human race the pleasure of achieving the ultimate: immortality.

While immortality would certainly be cool, the real (secret) objective is to focus our collective attention on a positive goal. Something that helps us feel hope and excitement for the future. I personally love the idea of having a child-like mind, 18-year-old physical vibrancy, and a lifetime of wisdom.

This 2039 goal is as much about AI as it is about us humans. It’s about how we survive giving birth to superintelligence. It’s kind of a big deal. We haven’t done it before. A lot can go wrong.

I figure that one of the best ways to improve the probability that we build safe AI, and don’t kill each other in the meantime, is to transform our shared aspirations from yolo to don’t die.

Right now, we are a suicidal species. We do all kinds of really primitive shit. We unnecessarily kill ourselves with what we eat and how we live our lives. Companies make profits from killing other people with their products. We trash the only home we have. We celebrate these things as virtue. It’s really fucked up and backward. Soon enough we’ll realize just how infantile we are right now.

The 2039 goal points us in the right direction.

To say yes to life and no to death. Defiance even.

If you’re interested in doing this with me, I’ll continue to share everything I do for free. I’m also going to build this out in Blueprint. We’ll help you do exactly what I’m doing, at a fraction of the cost and effort, alongside an aligned and motivated community.

I think this is the coolest goal imaginable. I find it hard to believe that of all the people who’ve lived, it’s us who get the opportunity to have this moment.

I pray that we have the courage to appreciate the sacredness of our existence. I pray that we will be brave enough to defend her amidst the onslaught of all the forces that would try to end her.

We don’t know, but we may be the only intelligent life to exist in our corner of the galaxy. I pray we will be warriors, caretakers and stewards of existence and honor the gift that has been bestowed on us.

2 days ago | [YT] | 10,349

Bryan Johnson

Jet lag is a metabolic stressor. Traveling 16 time zones significantly weakened my blood sugar control.

+ Mean glucose: 9.7% increase
+ Variability (SD): 15.8% increase
+ >100 mg/dL: 122% increase
+ >140 mg/dL: 0 to 1.37% (19 min from exercise)

2 days ago | [YT] | 720

Bryan Johnson

2026 will be the death of yolo

3 days ago | [YT] | 3,489

Bryan Johnson

how china views the u.s.

spotted in the chongqing airport

what do you see

3 days ago | [YT] | 933

Bryan Johnson

reclaim yourself

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6 days ago | [YT] | 15,812