My magic mushroom longevity experiment found a metabolic reset button in the brain. We expected brain changes, but not a potential metabolic breakthrough.
The discovery: my blood glucose control dramatically improved.
+ before: top 2% of population + after: top 0.2% of population + better than 99.75% of 18-25 yr olds + mean glucose dropped 8% + time above 125 mg/dL: zero min + variability dropped 11%
This single session reduced my estimated HbA1c by 6.8% from 4.7% to 4.4%.
Why does this matter? We treat diabetes and metabolic dysfunction with chronic daily medication (Metformin, Insulin, GLP-1s). This data suggests that a neuroplastic event might have downstream effects on the liver and pancreas that mimic or exceed these drugs.
For context, taking Metformin daily takes 6 months to drop it 10-15%.
This is a first in-human observation, with comparable pre-clinical evidence existing only in rodents.
Bryan Johnson
My magic mushroom longevity experiment found a metabolic reset button in the brain. We expected brain changes, but not a potential metabolic breakthrough.
The discovery: my blood glucose control dramatically improved.
+ before: top 2% of population
+ after: top 0.2% of population
+ better than 99.75% of 18-25 yr olds
+ mean glucose dropped 8%
+ time above 125 mg/dL: zero min
+ variability dropped 11%
This single session reduced my estimated HbA1c by 6.8% from 4.7% to 4.4%.
Why does this matter? We treat diabetes and metabolic dysfunction with chronic daily medication (Metformin, Insulin, GLP-1s). This data suggests that a neuroplastic event might have downstream effects on the liver and pancreas that mimic or exceed these drugs.
For context, taking Metformin daily takes 6 months to drop it 10-15%.
This is a first in-human observation, with comparable pre-clinical evidence existing only in rodents.
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