The project aims to develop and validate non-invasive exhaled breath aerosol (XBA) sampling methods combined with multiplex molecular detection to diagnose and screen respiratory infections with pandemic potential. Regardless of symptoms, the aim of this approach is to detect multiple pathogens from a single sample and is adaptable to emerging pathogens. The goal is to enhance pandemic preparedness, improve the diagnosis of respiratory illnesses, and reduce healthcare burden by enabling more accessible and scalable testing, potentially including self-sampling and self-testing.