The La Jolla Band of Luiseño Indians is a federally recognized tribe of Luiseño (Payómkawichum) people located in northern San Diego County, California. The tribe is part of the larger Luiseño nation, whose traditional territory spans much of Southern California. Today, the La Jolla Band has around 700 enrolled members, with approximately 390 living on the reservation. Members speak a mix of Luiseño, English, and Spanish.

The La Jolla Indian Reservation encompasses nearly 10,000 acres of land in the eastern foothills of the Palomar Mountains. The terrain ranges from rugged mountain slopes down to the San Luis Rey River, which runs through the heart of the reservation. Originally established through a series of executive orders between 1875 and 1892, the current boundaries were finalized on September 13, 1892.