MODUL4R (industrial manufacturing strategies for distributed control and resilient, rapidly responsive, and reconfigurable supply chains) is a 42-month project funded by Horizon Europe programme that aims to advance manufacturing with robust and autonomous modular production lines and supply chains. These advancements will allow for a low-volume production of new products in a cost-efficient manner, while providing the ability to rapidly adapt to unexpected situations and fluctuating supply chains. MODUL4R will validate its innovations and strategies through implementation in three representative use-cases namely: flexible and modular CPPS for automatised assembly of printed circuit boards (PCBs), specialised mould manufacturing for the automotive sector, and highly customised taps for application in aero and windmill manufacturing.