Progress Report on the Cell Observatory Initiative

"How Large Language Models impact Bio-image Data Science."

Sexual dimorphism in the fruit fly central nervous system

Example visual-motor pathway in the fruit fly

Male fruit fly CNS cell types

New research shows how longevity is inherited across generations

iGluSnFR4

iGABASnFR2

FuncEWOrm project C. elegans embryo

Claire Deo: "Chemigenetic Molecular Tools for Biological Imaging Across Scales"

Visual stimulus presentation and simultaneous neural imaging

Visualizing neural activities using Rastermap with behavioral annotations.

Plasticity in the visual cortex after supervised and unsupervised training

Andrew Moore: Untangling Intermediate Filament Biology with FilaBuster: A New Tool for Light-Cont...

Larval zebrafish swim behavior in a closed and open loop

Simultaneous recordings of intracellular calcium in astrocytes and extracellular ATP

Deep learning in development biology

Rory Power: Advanced custom microscopy development for service provision at the EMBL Imaging Centre

So Far: Content-aware Denoising and Semantic Unmixing

Transcriptional regulation of metabolism

Decoding and Translating the Languages of Biology

CellposeSAM: superhuman generalization for cellular segmentation

Towards predictive models of the protein sequence determinants of nuclear condensates

Global views of development

Genome-scale models of metabolic wiring and rewiring

The role of signaling beyond the nearest neighbors in preimplantation mouse development

Decoding human cell architectures - from spatial proteomics to whole cell modelling

Multimodal Data Integration: From Biomarkers to Mechanisms

AI-Accelerated Discovery of Body-Wide Cellular Communication Networks: Creating a New Scientific...

Contrastive Learning for Cross-domain Reconciliation and Discovery

A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function

Intracellular cartography of the human proteome

Large synthetic image datasets to train foundation models for cell segmentation

Reformation Is All You Need

Building a Petabyte-Scale Pipeline For AI-Accelerated in vivo Cell Biology

Bridging the Tissue and Organelle Scales with Spatial Organellomics

Understanding the Sources of Regenerative Capacity In Animals

DELTA measures synaptic turnover of GluA2

New imaging tool maps brain-wide changes in neuronal connections

New method uses DNA barcodes for high throughput RNA and protein detection in deep tissue

High throughput protein detection in deep tissue using cycleHCR

New imaging method reveals the 3D arrangement of molecules inside cells

Predator robots help researchers uncover how larval zebrafish rapidly learn

Imaging neural activity in the hippocampus during learning

Learning to navigate two different virtual corridors

Neural activity with increasing number of cells plotted

Cellpose3 can spot cell boundaries even in cloudy conditions

Lysosome trafficking through laddered endoplasmic reticulum and its impact on ER organization

Stable endoplasmic reticulum - plasma membrane junctions compared with dynamic laddered ER elements

High-resolution imaging reveals ladder-like structure of the endoplasmic reticulum in neurons

3D rendering of an excitatory neuron cell and cilium

New AI technique generates clear images of thick biological samples without the fancy hardware

Reconstructed 3D movie of ribosome moving through the elongation cycle

Reconstructed 3D movie of ribosome and binding partners moving through the elongation cycle.

Astroglial calcium wave in the larval zebrafish brain in response to acute ketamine treatment.

Discouraged zebrafish help reveal how ketamine works in the brain

Zebrafish in the assay for futility-induced passivity or “giving up” behavior.

Fighting female fruit flies

New research finds how fighting female flies focus on their foes

PetaKit5D: a comprehensive suite of software tools for processing petabyte-scale microscopy data