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Paget’s disease of bone, also known as osteitis deformans, occurs when new bone is generated faster than normal, resulting in the disorganized, weaker, and less compact bone, primarily the spine, pelvis, skull, femur, and tibia. It affects elderly, approximately 3% of individuals over the age of 40 years.

For those with symptoms, pain is generally the first thing they experience; bone weakness and fractures develop later. The symptoms and sequelae of Paget’s disease can be memorized with the mnemonic PANICS:

Pain

Arthralgia

Nerve compression/Neural deafness

Increased bone density

Cardiac failure, and

Skull/Sclerotic vertebrae/Sarcomas (osteosarcomas)

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