Scientists studied Maria Branyas, the world’s oldest person, using multi-omics (genomics, proteomics, etc.) to map her biology. Spoiler: It’s a mix of good genes and body hacks fighting aging. 🧬👵
Methods: They analyzed blood samples for DNA, proteins, metabolism, gut bacteria, and more—without invasive tests. Compared her to typical 100-year-olds and younger folks. This is the deepest dive into a supercentenarian yet. 🔬
Aging signs were there: Super short telomeres (like frayed chromosome ends), mutations in blood cells (clonal hematopoiesis), and more age-related B cells in her immune system. Her body showed extreme age—but handled it like a boss. ⏳
Protective genes: Rare variants that shield the heart and brain from damage. Think built-in armor against heart disease and neurodegeneration. These aren’t common, but they might explain why she dodged major illnesses. ❤️🧠
Metabolism win: Active lipid (fat) processing kept things balanced. No high cholesterol or diabetes markers—her body efficiently managed energy, avoiding common old-age pitfalls. ⚡
Low inflammation: Unlike most elderly, her inflammation levels were chill, reducing wear and tear on organs. Plus, an efficient immune response that fought threats without overreacting. 🛡️
Gut health bonus: A “rejuvenated” microbiome full of beneficial bacteria like bifidobacteria, similar to younger people. This supports digestion, immunity, and overall vibe - and she ate Mediterranean-style foods: olive oil, fish, and 3 servings of plain yogurt daily. 🦠
Epigenetic youth: Her “epigenetic clocks” (DNA markers of biological age) ticked slower—she was epigenetically younger than her 117 years. This deceleration might be key to her extra decades. 🕰️
Big picture: No magic pill, but this shows longevity comes from genes, low inflammation, strong immunity, and a young-like biology. Could inspire treatments for aging diseases.
Ben Greenfield Life
This woman lived to 117: here’s what her genes and lifestyle tell us about longevity - www.nature.com/articles/d41586-025-03112-6
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Scientists studied Maria Branyas, the world’s oldest person, using multi-omics (genomics, proteomics, etc.) to map her biology. Spoiler: It’s a mix of good genes and body hacks fighting aging. 🧬👵
Methods: They analyzed blood samples for DNA, proteins, metabolism, gut bacteria, and more—without invasive tests. Compared her to typical 100-year-olds and younger folks. This is the deepest dive into a supercentenarian yet. 🔬
Aging signs were there: Super short telomeres (like frayed chromosome ends), mutations in blood cells (clonal hematopoiesis), and more age-related B cells in her immune system. Her body showed extreme age—but handled it like a boss. ⏳
Protective genes: Rare variants that shield the heart and brain from damage. Think built-in armor against heart disease and neurodegeneration. These aren’t common, but they might explain why she dodged major illnesses. ❤️🧠
Metabolism win: Active lipid (fat) processing kept things balanced. No high cholesterol or diabetes markers—her body efficiently managed energy, avoiding common old-age pitfalls. ⚡
Low inflammation: Unlike most elderly, her inflammation levels were chill, reducing wear and tear on organs. Plus, an efficient immune response that fought threats without overreacting. 🛡️
Gut health bonus: A “rejuvenated” microbiome full of beneficial bacteria like bifidobacteria, similar to younger people. This supports digestion, immunity, and overall vibe - and she ate Mediterranean-style foods: olive oil, fish, and 3 servings of plain yogurt daily. 🦠
Epigenetic youth: Her “epigenetic clocks” (DNA markers of biological age) ticked slower—she was epigenetically younger than her 117 years. This deceleration might be key to her extra decades. 🕰️
Big picture: No magic pill, but this shows longevity comes from genes, low inflammation, strong immunity, and a young-like biology. Could inspire treatments for aging diseases.
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