Dr. Annette Bozworth, know as simply Dr. Boz by her online followers, has been preaching sardine fasting for her most insulin resistant patients for years now. Turns out she was very insightful. This just goes to show you that sometimes clinicians who have the temerity to try something new are, in many cases, ahead of the science.
6 days ago (edited) | 34
I gotta check this out. My Achilles heel is how cold adaptive thermogenesis makes me
4 days ago | 0
I tried it after watching the video.... unfortunately, I couldn't go more than a week. Started experiencing intense nausea, and something about the sardines just didn't sit right with my stomach (tried several brands).
6 days ago | 11
I wonder if this is why I go without a jacket this time of the year in UK and always feel hot and sweaty 😮
4 days ago | 0
Sardines could supercharge my metabolism, make me look like I was 18 again, and give me a million bucks and I still wouldn't eat them 😂
5 days ago | 0
Has anyone seen the Studies on Cold water Divers & swimmers in South Korea, regarding effects on Basal Metabolic Rate (BMR) & Brown Fat Cells + implications for Metabolic panel? 🇰🇷🌊🏊♀
5 days ago (edited) | 1
These n of 1 stories are pretty useless. Genes. Biome. Anyone with a histamine or purine issue can't do lots of tinned fish. Metals never gets discussed. The nuances aren't there
5 days ago | 1
The no 1 biomarker for how well you will age is natural hormone production. When hormones decline health and wellness declines. Sarcopenia arrives loss of bone density and reduced activity levels along with cognitive decline poor moods and increased stress. This is why all biohackers are on TRT to attempt to compensate for this deficit. I went from 334 to 960 in around three months all natural no TRT. This book should be essential reading for all men. Written by a 50s guy with natural T levels higher than most 20s guys Complete guide to testosterone by james Francis
4 days ago | 1
I wish I could try this but I'm not a fan of any fish. I couldn't even fathom putting one in my mouth let alone trying to live off them for extended periods lol. Hats off to ya Nick for your ability to do so and for sharing your experience with us.
6 days ago | 2
Sardines are some of the most flavor less fish ever. The olive oil is all I taste. I don’t really get how people always get grossed out by them. To each their own though. Great way to get those ketones rockin. Very interesting with the cold tolerance/brown fat benefits. Thanks!!
4 days ago | 0
How much sardines can I eat a day if I want to eat other things as well? I think you did a sardines only diet, I don't think I can do that, but I am happy eating sardines every day as part of my diet, and have been eating 1 can a day for a few months.
6 days ago | 4
Nick Norwitz
I accidentally supercharged my metabolism with sardines 🐟⚡
Link: staycuriousmetabolism.substack.com/p/the-weird-ant…
After sharing my Sardine Diet experiment, one unexpected side effect stood out: I became oddly cold-resistant.
Imagine standing shirtless in a Boston winter and feeling... fine. Almost comfortable.
Strange? Yes. But also grounded in biochemistry.
As I dug into the literature, a fascinating pathway emerged.
It turns out metabolically active brown fat can convert omega-3s into a signaling molecule called 12-HEPE. This molecule ramps up thermogenesis (heat production), pulls glucose into muscle, and boosts energy expenditure.
It’s a cold-adaptation mechanism—but fueled by omega-3s, not just temperature.
In humans, activating this pathway pharmacologically led to a surge in 12-HEPE and increased glucose uptake into brown fat—a metabolic shift toward heat.
There are also data showing that obesity is a 12-HEPE-deficient state.
Interesting… 🤔
There’s a lot more to unpack—including the full study data and some surprising insights from my own experiment.
If you’re interested in:
👉 The metabolic power of brown fat
👉 Why omega-3s may do more than just fight inflammation
👉 What cold exposure teaches us about fat-burning…
Check out the full letter (linked above).
#Metabolism #Longevity #HealthTech #SelfExperimentation #NutritionScience #Omega3 #BrownFat #GlucoseMetabolism #FunctionalMedicine
6 days ago | [YT] | 861