Invidious

29:03

Every Biblical/Religious reference in The Binding Of Isaac explained

The Night Archives

Shared 1 year ago

358K views

18:37

Isaac, But The Enemies Drop Items! (OP)

Kayhos  

Shared 9 months ago

107K views

1:15:18

How To Play Isaac

Another Matt Playing Isaac

Shared 1 year ago

134K views

5:00

16 Unspoken Rules In The Binding Of Isaac

Kayhos  

Shared 9 months ago

51K views

37:04

The ULTIMATE Isaac Quiz Ft @lazymattman

Another Matt Playing Isaac

Shared 2 years ago

736K views

1:01

The Binding of Isaac Texturepack top 10 #repentance #tboi #isaac

Robi_63

Shared 9 months ago

350K views

2:29

The CREEPIEST Isaac Boss EVER! Cacophobia (Fiend Folio)

SlayXc2  

Shared 3 years ago

3.1M views

36:26

Teaching a BEGINNER how to Play Isaac

Another Matt Playing Isaac

Shared 1 year ago

112K views

38:14

Your Isaac Challenges are TERRIBLE

Another Matt Playing Isaac

Shared 1 week ago

38K views

1:06:48

Isaac CHARACTERS Tips & Tricks

Another Matt Playing Isaac

Shared 2 years ago

442K views

26:22

Isaac Speedruns are INSANE

Another Matt Playing Isaac

Shared 1 year ago

202K views

3:22

ISAAC : ሀ’ ስል | HUSTLE. NEW ETHIOPIAN MUSIC 2025 (official video)

Isaac Addisu  

Shared 1 year ago

218K views

10:29

What Isaac Did To His Teacher In Class🤣🤣

Kat The Comedian malome kat  

Shared 1 year ago

1.6M views

28:57

Isaac TRANSFORMATIONS Ranked By Their IMPACT

Another Matt Playing Isaac

Shared 2 years ago

243K views

16:43

Isaac, But There Is A 1% Chance To Spawn Bestia...

Kayhos  

Shared 9 months ago

86K views

8:45

Isaac and Blessing Outsmarted Their Greedy Uncle.🤣😂

Kat The Comedian malome kat  

Shared 1 year ago

283K views

1:19:07

Genesis 25:1 to 26:35 #esau #isaac #jacob #abraham #arab #arabs #rebekah #birthright #ishamel #well

Robert Breaker  

Shared 1 month ago

11K views

20:30

The Ultimate Guide to the Binding of Isaac: Path to Dead God

Priets

Shared 4 years ago

1.7M views

14:01

Everything You NEED To Know About The Binding Of Isaac

Party

Shared 1 year ago

8.1K views

38:37

Your Isaac Challenges are a NIGHTMARE

Another Matt Playing Isaac

Shared 1 month ago

51K views

15:37

Do NOT Play Isaac's Enemy Randomizer...

Another Matt Playing Isaac

Shared 1 year ago

147K views

1:12:02

I Challenged the "Archipelago Guy" to ISAAC BINGO

Another Matt Playing Isaac

Shared 1 month ago

78K views

0:32

The Binding of Isaac Texturepack top 12 #repentance #tboi #isaac

Robi_63

Shared 2 months ago

12K views

52:14

I was challenged to Binding of Isaac BINGO

cjya  

Shared 3 months ago

196K views

3:04

Papa Héros cover by branel #isaac le rossignol

studio Live CG

Shared 1 year ago

45K views

31:44

Isaac, But Two People Control One Character…

Kayhos  

Shared 11 months ago

63K views

1:27:53

RUN OF THE YEAR? - The Binding Of Isaac Repentance+ #543

Sinvicta  

Shared 1 month ago

59K views

38:01

Don't sleep on SANGUINE BOND! - The Binding Of Isaac Repentance+ #584

Sinvicta  

Shared 1 week ago

17K views

29:12

The ULTIMATE Isaac Race: The Wiz vs 20/20

Another Matt Playing Isaac

Shared 1 year ago

114K views

41:46

TRISTONE! - The Binding Of Isaac Repentance+ #585

Sinvicta  

Shared 6 days ago

21K views

3:40

TÂM Ý ĐỔI THAY | OFFICIAL VISUALIZER | ISAAC x YEOLAN

Isaac Official  

Shared 2 months ago

677K views

57:11

Isaac's CHAPTER 1 Enemy Tournament

Another Matt Playing Isaac

Shared 2 weeks ago

71K views

9:14

Isaac In Class.. 🙆‍♂️🤣🤣🤣 Trouble boy

Kat The Comedian malome kat  

Shared 1 year ago

850K views

40:36

We UPDATED Isaac Bingo.. its CRAZY

Another Matt Playing Isaac

Shared 2 months ago

58K views

58:37

HEARTBREAK - The Binding Of Isaac Repentance+ #590

Sinvicta  

Shared 1 day ago

13K views

18:50

How To Farm Items In Binding Of Isaac

Kayhos  

Shared 6 months ago

38K views