Invidious

55:32

Is Star Of Bethlehem THE BEST Angel Item? - The Binding Of Isaac #658

Sinvicta  

Shared 18 hours ago

17K views

29:03

Every Biblical/Religious reference in The Binding Of Isaac explained

The Night Archives

Shared 1 year ago

495K views

23:56

Ranking Isaac's WORST Items

Another Matt Playing Isaac  

Shared 1 week ago

119K views

10:29

What Isaac Did To His Teacher In Class🤣🤣

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Shared 1 year ago

1.7M views

1:15:18

How To Play Isaac

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Shared 1 year ago

160K views

1:09:23

Isaac Bingo but we can CHEAT

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Shared 1 month ago

92K views

1:01

The Binding of Isaac Texturepack top 10 #repentance #tboi #isaac

Robi_63

Shared 11 months ago

372K views

2:31:54

So Isaac has an IMPOSSIBLE Mod.

Another Matt Playing Isaac  

Shared 1 month ago

205K views

51:29

I Tried Beating Your TERRIBLE Isaac Challenge. I am going insane.

Another Matt Playing Isaac  

Shared 4 days ago

93K views

37:04

The ULTIMATE Isaac Quiz Ft @lazymattman

Another Matt Playing Isaac  

Shared 2 years ago

804K views

2:29

The CREEPIEST Isaac Boss EVER! Cacophobia (Fiend Folio)

SlayXc2  

Shared 4 years ago

3.2M views

40:36

We UPDATED Isaac Bingo.. its CRAZY

Another Matt Playing Isaac  

Shared 5 months ago

82K views

1:06:48

Isaac CHARACTERS Tips & Tricks

Another Matt Playing Isaac  

Shared 2 years ago

505K views

56:02

Beginner's Guide to the Binding of Isaac

Another Matt Playing Isaac  

Shared 2 months ago

124K views

1:31:52

Finally solving Isaac after 15 years | Binding of Isaac

It's The pizza boy

Shared 1 week ago

153K views

52:02

Your Isaac Challenges are INSANE

Another Matt Playing Isaac  

Shared 3 weeks ago

90K views

26:22

Isaac Speedruns are INSANE

Another Matt Playing Isaac  

Shared 1 year ago

270K views