Invidious

29:03

Every Biblical/Religious reference in The Binding Of Isaac explained

The Night Archives

Shared 1 year ago

421K views

1:15:18

How To Play Isaac

Another Matt Playing Isaac

Shared 1 year ago

149K views

2:31:54

So Isaac has an IMPOSSIBLE Mod.

Another Matt Playing Isaac

Shared 3 weeks ago

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1:33:22

The Sword That BROKE Isaac - The Binding Of Isaac Repentance+ #628

Sinvicta  

Shared 11 hours ago

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1:06:48

Isaac CHARACTERS Tips & Tricks

Another Matt Playing Isaac

Shared 2 years ago

472K views

45:31

He Challenged Me to an Isaac Bingo REMATCH. Big Mistake.

Another Matt Playing Isaac

Shared 1 month ago

75K views

26:22

Isaac Speedruns are INSANE

Another Matt Playing Isaac

Shared 1 year ago

240K views

2:29

The CREEPIEST Isaac Boss EVER! Cacophobia (Fiend Folio)

SlayXc2  

Shared 3 years ago

3.2M views

1:01

The Binding of Isaac Texturepack top 10 #repentance #tboi #isaac

Robi_63

Shared 10 months ago

360K views

10:29

What Isaac Did To His Teacher In Class🤣🤣

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1.6M views

58:26

Ranking Isaac BIRTHRIGHTS By Their USEFULNESS

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Shared 2 years ago

384K views

37:04

The ULTIMATE Isaac Quiz Ft @lazymattman

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Shared 2 years ago

774K views

56:02

Beginner's Guide to the Binding of Isaac

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Shared 1 month ago

83K views

3:22

ISAAC : ሀ’ ስል | HUSTLE. NEW ETHIOPIAN MUSIC 2025 (official video)

Isaac Addisu  

Shared 1 year ago

224K views

25:17

Another UNWINNABLE Isaac Seed Just Dropped

Another Matt Playing Isaac

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189K views

32:54

30 minutes of pointless Isaac trivia

It's The pizza boy

Shared 7 months ago

106K views