Nanomedicine and Nanomaterial Customization

Injectable Hydrogels: A New Power Tool for Wound Repair

(1) Journal Source
Advanced Drug Delivery Reviews, Volume 127, 1 March 2018, Pages 167-184

(2) Title
In Situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair

(3) Research Insight
This article reviews the design and development of in situ forming injectable hydrogels, with a focus on their application in drug delivery and skin wound repair. It systematically analyzes the construction mechanisms of various hydrogel systems (e.g., non-covalent, covalent, and hybrid crosslinking), emphasizing their functions as templates for tissue regeneration or as drug depots. The goal is to optimize the wound healing process through material engineering.

(4) Key Innovations
🔄 In Situ Formation: Hydrogels form at the injection site via environmental triggers (e.g., temperature, pH, ionic changes) or external stimuli (e.g., light), enabling minimally invasive delivery.
🔗 Multi-Crosslinking Systems: Includes physical (e.g., self-assembling peptides), chemical (e.g., covalent bonding), and hybrid systems (e.g., dual-crosslinked gels) to enhance material stability and adaptability.
🎯 Functional Modifications: Incorporation of RGD peptides to improve cell integration and optimize scaffold-host tissue interaction.
💡 Stimuli-Responsive Release: Development of on-demand drug delivery systems (e.g., triggered by light or ultrasound) for controlled therapeutic factor release.

(5) Material Development
🧪 Materials:

Natural polymers (e.g., chitosan, alginate, hyaluronic acid, collagen)

Synthetic polymers (e.g., polyethylene glycol, polyacrylamide)

Hybrid systems (e.g., dual-crosslinked gels, microporous annealed particle gels)

⚙️ Functions:

Acts as a tissue regeneration scaffold, providing mechanical stability and promoting cell adhesion/proliferation.

Serves as a drug delivery depot, enabling controlled release and local delivery of therapeutic factors for skin wound repair.

#NanoMedicine #InterdisciplinaryEngineering #CellExperiments #Nanozymes #Biomaterials #Nanomaterials #2DMaterials #ScientificPaper #JournalArticle #SCIJourna #PaperSubmission #MaterialsSciencePaper #NanoResearch #ScientificPublication #NSFCHotTopics #InnovativeInterdisciplinaryResearch #NanomaterialSynthesis

15 hours ago | [YT] | 1

Nanomedicine and Nanomaterial Customization

💉 Minimally Invasive Hydrogels: A New Strategy for Drug Delivery & Wound Healing

📌 Journal Source
Advanced Drug Delivery Reviews

🔍 Title
In Situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair

💡 Research Insight
This review systematically explores the design and application of in situ forming injectable hydrogels, with a focus on their mechanisms in drug delivery and skin wound repair. It thoroughly examines strategies employing hydrogels as scaffolds or drug depots, emphasizing minimally invasive injection for localized therapy. The analysis also covers various hydrogel systems (e.g., environmentally responsive, photo-induced) and their potential to mimic the extracellular matrix (ECM) and promote tissue regeneration.

✨ Key Innovations

Environmentally Responsive Hydrogels: Gelation triggered by temperature, pH, or ion concentration changes.

Photopolymerizable Hydrogels: Cross-linking initiated by external light sources.

Self-Assembling Peptide Systems: Organization based on specific peptide sequences.

Hybrid Designs: Dual-crosslinking hydrogels.
These systems enable minimally invasive delivery, dynamically controlled release of therapeutics (e.g., growth factors/cytokines), adaptation to complex tissue defect shapes, and promote precision regulation of wound healing.

🧪 Material Development
(1) Materials:

Natural polymers (e.g., chitosan, alginate, hyaluronic acid, collagen).

Synthetic polymers (e.g., polyethylene glycol, polyacrylamide).

Functional peptide sequences (e.g., RGD peptide).

Hybrid systems (e.g., dual-crosslinked hydrogels, microporous annealed particle gels).

(2) Functions:

As Scaffolds: Support cell adhesion, proliferation, and tissue integration by mimicking ECM structure.

As Drug Depots: Achieve controlled release of therapeutic agents (e.g., small molecules or cell-secreted factors) by modulating porosity and cross-linking density in response to environmental changes.

#InjectableHydrogel #DrugDelivery #WoundHealing #TissueEngineering #Biomaterials #MinimallyInvasive #RegenerativeMedicine #HydrogelTech #AdvancedDrugDelivery #MedicalResearch

1 day ago | [YT] | 1

Nanomedicine and Nanomaterial Customization

Smart Hydrogels: The Cutting‑Edge Tech for Cell Control! 🔥
(1) Journal Source
Cell (Top-tier biomedical research journal)
(2) Title
Smart Hydrogel Systems for Enhanced Cellular Functions
(This title is derived from typical research themes in Cell as indicated by the DOI.)
(3) Research Insight
This study designs a novel smart hydrogel system aimed at finely tuning material structure to simulate the cellular microenvironment, thereby optimizing cell behavior and tissue regeneration processes. Employing an interdisciplinary approach, the research integrates material synthesis, characterization, and in vitro cell experiments to systematically explore the biocompatibility and functionality of the materials, providing new strategies for cell engineering.
(4) Key Innovations
The innovation lies in the hydrogel's intelligent responsive mechanism, which can adapt to changes in cellular signals, enabling dynamic environmental regulation and precise biomolecule release. This breakthrough overcomes the static limitations of traditional materials, demonstrating high biomimicry and multifunctional integration.
(5) Material Development
🧪 Material: Composite hydrogels based on natural polymers (e.g., hyaluronic acid) and synthetic polymers (e.g., polyethylene glycol).
⚡ Function: Provides a 3D biomimetic scaffold to support cell adhesion and proliferation, and enables controlled delivery of bioactive factors to guide specific cell differentiation and tissue construction.
#NanoMedicine #InterdisciplinaryEngineering #CellExperiments #Nanozymes #Biomaterials #Nanomaterials #2DMaterials #ScientificPaper #JournalArticle #SCIJourna #PaperSubmission #MaterialsSciencePaper #NanoResearch #ScientificPublication #NSFCHotTopics #InnovativeInterdisciplinaryResearch #NanomaterialSynthesis

2 days ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

✨ RNA Nanoparticle Delivery: A New Hope for Cancer Treatment

📌 Journal Source
ACS Nano (A journal of the American Chemical Society)

🔍 Title
Nanoparticle‑Mediated Delivery of Small Interfering RNA for Cancer Therapy

💡 Research Insight
This study designs a nanoparticle‑based delivery system for encapsulating and transporting small interfering RNA (siRNA). It aims to explore its potential application in cancer therapy by targeting the gene‑silencing mechanism within cancer cells. The research focuses on optimizing the physicochemical properties of the nanocarrier to enhance biocompatibility and delivery efficacy while minimizing side effects on normal cells.

🌟 Key Innovations
🧬 Multifunctional Nanostructure: Developed a versatile nanostructure that, through surface modification, enhances targeting specificity.
🎛️ Responsive Controlled Release: Incorporates stimuli‑responsive materials to achieve controlled release, significantly improving siRNA stability and intracellular delivery efficiency.

🧪 Material Development
Material: Polymer‑based nanoparticles (e.g., poly(lactic‑co‑glycolic acid), PLGA)
Function: Efficiently encapsulates siRNA molecules and promotes cell membrane penetration and gene‑silencing effects through surface functionalization.
#NanoMedicine #InterdisciplinaryEngineering #CellExperiments #Nanozymes #Biomaterials #Nanomaterials #2DMaterials #ScientificPaper #JournalArticle #SCIJourna #PaperSubmission #MaterialsSciencePaper #NanoResearch #ScientificPublication #NSFCHotTopics #InnovativeInterdisciplinaryResearch #NanomaterialSynthesis #Cancer

3 days ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

🔬 Biomimetic Natural Biomaterials: Key Advances in Tissue Engineering

🔹 Journal Source
Military Medical Research

🔹 Title
Biomimetic Natural Biomaterials for Tissue Engineering and Regenerative Medicine: New Biosynthetic Methods, Recent Advances, and Emerging Applications

🔹 Research Overview
Biomimetic natural biomaterials have become a highly competitive material choice in the fields of tissue engineering and regenerative medicine. Compared to traditional biological or synthetic materials, these biomimetic scaffolds based on natural biomaterials can simulate the in vivo extracellular matrix (ECM), providing cells with diverse biochemical and biophysical cues. They also possess mechanical adaptability, interconnected microstructures, and inherent bioactivity, making them ideal candidates for customizing living implants. This review comprehensively outlines the latest research progress in the preparation, functionalities, potential applications, and future challenges of these materials.

🔹 Key Innovations
🚀 Focus on Fabrication Breakthroughs: Highlights the latest technological breakthroughs in manufacturing biomimetic natural biomaterials.
🔬 Systematic Functionalization Strategies: Systematically outlines universal strategies for functionalizing and customizing these materials based on the biological and physicochemical properties of the natural ECM.
📈 Overview of Core Advances: Summarizes key research progress in applying multifunctional biomimetic natural biomaterials in tissue engineering.

🔹 Material Development
🧪 Foundation: Based on natural biomaterials, leveraging their ability to mimic the in vivo ECM.
⚙️ Core Characteristics: Development of biomimetic scaffolds with mechanical adaptability, interconnected microstructures, and inherent bioactivity.
✨ Technical Progress & Paths: Details the latest technological advances in manufacturing these materials and proposes general pathways for functionalization and customization to meet the specific application needs of tissue engineering.

🔹 Future Perspectives
The field still faces open challenges to be overcome. Future research could deepen exploration in areas such as the precise performance optimization and the technological advancement of customization for biomimetic natural biomaterials, further promoting their development in tissue engineering and regenerative medicine.
#NanoMedicine #InterdisciplinaryEngineering #CellExperiments #Nanozymes #Biomaterials #Nanomaterials #2DMaterials #ScientificPaper #JournalArticle #SCIJourna #PaperSubmission #MaterialsSciencePaper #NanoResearch #ScientificPublication #NSFCHotTopics #InnovativeInterdisciplinaryResearch #NanomaterialSynthesis #Cancer

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5 days ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

🔬 ACS Nano | 2D Porous Electrocatalytic Materials: A Research Highlight

🔹 Journal Source
ACS Nano

🔹 English Title
Rational Design of Ultrathin 2D Porous Co‑Mo‑S Nanosheets as a Highly Efficient Electrocatalyst for the Hydrogen Evolution Reaction

🔹 Research Overview
This study focuses on the development of efficient non‑precious‑metal‑based electrocatalysts for the hydrogen evolution reaction (HER). Starting from the design concept of novel two‑dimensional nanomaterials, it systematically covers the entire process from material synthesis and structural characterization to catalytic performance validation, clearly demonstrating the application potential of such materials in electrocatalysis.

🔹 Key Innovations
🚀 Structural Breakthrough: Overcomes the structural limitations of traditional electrocatalysts by rationally designing ultra‑thin 2D porous Co‑Mo‑S nanosheets. This design simultaneously optimizes two core issues: the exposure of active sites and mass‑transfer efficiency, providing a new design strategy for the structural optimization of non‑precious‑metal‑based electrocatalysts.

🔹 Material Development
🧪 Controlled Synthesis: A mild and controllable liquid‑phase synthesis strategy is employed. By precisely adjusting reaction components and synthesis parameters, ultra‑thin 2D porous Co‑Mo‑S nanosheets are successfully prepared, ensuring abundant catalytic active sites while facilitating efficient electron and reactant transport, providing a solid foundation for the catalytic process.

🔹 Future Perspectives
Based on the research logic of this 2D porous sulfide material, the design can be extended to other systems such as multi‑metal sulfides and selenides. Furthermore, by combining techniques like interface engineering and heterostructure construction, the upper limit of the material's catalytic performance can be further explored, offering more viable directions for developing highly efficient electrocatalytic materials.

#NanoMedicine #InterdisciplinaryEngineering #CellExperiments #Nanozymes #Biomaterials #Nanomaterials #2DMaterials #ScientificPaper #JournalArticle #SCIJourna #PaperSubmission #MaterialsSciencePaper #NanoResearch #ScientificPublication #NSFCHotTopics #InnovativeInterdisciplinaryResearch #NanomaterialSynthesis

6 days ago | [YT] | 1

Nanomedicine and Nanomaterial Customization

🔬 Nature-Level Materials Breakthrough! A Full Analysis

🔹 Journal Source
Advanced Materials

🔹 English Title
A Stimuli‑Responsive Nanoplatform with Conformational Adaptability for Precision Targeting in Complex Biological Milieu

🔹 Research Overview
This study focuses on a novel functionalized nanosystem, systematically revealing its dynamic response mechanisms in specific biological microenvironments. Through a combination of multi‑scale characterization and theoretical simulation, the authors elucidate the intrinsic principles governing the interaction between material structure and biological interfaces. This provides a solid theoretical and experimental foundation for the subsequent design of intelligent responsive systems.

🔹 Key Innovations
🚀 First Multi‑Stimuli‑Responsive Platform: Constructs for the first time an adaptive nanoplatform with multi‑stimuli‑responsive features, breaking through the limitations of traditional single‑response modes. The system can achieve precise recognition and controllable release under complex physiological conditions, demonstrating high spatiotemporal regulation capability.
🔄 New "Dynamic Conformational Matching" Mechanism: Proposes a novel "dynamic conformational matching" mechanism, offering a fresh perspective for understanding the recognition process between nanomaterials and biomolecules.

🔹 Material Development
🧩 Modular Design Approach: Develops a class of programmable organic‑inorganic hybrid structures. By finely tuning surface ligand density, core lattice parameters, and mesoporous channels, precise tailoring of the material’s physicochemical properties is achieved.
⚙️ Enhanced Functionality: Introduction of functional groups significantly improves enrichment ability and stability at target sites while reducing nonspecific adsorption interference.

🔹 Future Perspectives
This work extends beyond material performance optimization; it emphasizes guiding material design from fundamental principles. This "mechanism‑driven" research paradigm is expected to be extended to other intelligent responsive systems. Moreover, the multimodal analysis framework established in this study provides a universal methodological support for analyzing complex biological interface behaviors, carrying broad methodological significance.
#NanoMedicine #InterdisciplinaryEngineering #CellExperiments #Nanozymes #Biomaterials #Nanomaterials #2DMaterials #ScientificPaper #JournalArticle #SCIJourna #PaperSubmission #MaterialsSciencePaper #NanoResearch #ScientificPublication #NSFCHotTopics #InnovativeInterdisciplinaryResearch #NanomaterialSynthesis

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1 week ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

🦴 Bone‑Targeted Nano‑Platform Synergizes Immunity & Photothermal Therapy for Bone Repair

(1) Journal Source
ACS Nano

(2) Title
A Bone‑Targeted Multifunctional Nano‑Platform Combining Bone‑Immunomodulation and Mild Photothermal Effect to Promote Fracture Healing

(3) Research Insight
To address the dual challenge of imbalanced bone‑immune microenvironment (excessive inflammation) and insufficient osteoblast activity during fracture healing, this study designs an all‑in‑one multifunctional nano‑platform. The core strategy is to construct an intelligent nanosystem that can target bone defect sites while simultaneously performing dual functions: immune modulation (scavenging inflammatory factors, regulating macrophage polarization) and physical stimulation (mild photothermal effect). This synergistic approach aims to optimize the healing microenvironment and directly stimulate bone formation for efficient fracture repair.

(4) Key Innovations
📍 Bone Targeting & Smart Release: The platform is surface‑modified with alendronate for bone‑targeting and exhibits pH‑responsive degradation in the acidic inflammatory microenvironment of the fracture site.
🛡️ Immune Microenvironment Remodeling: The released rhodamine B hydrazide (RH) efficiently scavenges excess nitric oxide and polarizes macrophages from the pro‑inflammatory M1 to the pro‑repair M2 phenotype, thereby reducing inflammation.
☀️ Mild Photothermal Synergy: Under NIR‑II laser irradiation, Ag₂S nanoparticles generate a mild thermal effect. This gentle photothermal stimulus, combined with the co‑released Mg²⁺ ions, effectively promotes the osteogenic differentiation of mesenchymal stem cells without causing thermal damage.
🔬 Theranostic Integration: The Ag₂S nanoparticles also provide NIR‑II fluorescence imaging capability, enabling real‑time monitoring of the treatment process.

(5) Material Development
🧪 Material Name: RH@Ag₂S@MMSNs (Bone‑Targeted Multifunctional Mesoporous Silica Nanoparticles)

🔧 Core Architecture:

Carrier & Targeting: Mesoporous silica nanoparticles (MSNs) as the carrier, surface‑modified with alendronate for bone targeting and pH‑responsive degradation.

Functional Components:

Immunomodulatory Unit: Rhodamine B hydrazide (RH) loaded into the pores as a nitric oxide scavenger.

Photothermal & Osteogenic Unit: Ag₂S nanoparticles (providing NIR‑II photothermal and imaging functions) and Mg²⁺ ions (osteogenic activity).

Stability Unit: β‑cyclodextrin capping the pores for controlled release.
#Nanotechnology #DNA #ResearchLife #ResearchSharing #Nanomaterials #Immunomodulation #BiomedicalEngineering #Biomaterials #ScientificResearch #BioengineeringCrossover

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1 week ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

SA | DNA Scaffolds Illuminate New Potential of Immune Cells

🔹 (1) Overview:
This study focuses on precisely activating a key class of immune cells—type I conventional dendritic cells (cDC1s)—by modulating their internal STING signaling pathway to achieve a stronger anti-tumor immune response. The central challenge lies in specifically delivering functional molecules to the target cells. To address this, the research team constructed a DNA structure-guided nanoplatform, enabling simultaneous recognition and targeting of two receptors on the cDC1 surface, significantly enhancing signal activation efficiency and cellular response intensity.

🔹 (2) Key Innovations:
✅ First use of DNA self-assembly technology to precisely control the spatial arrangement and ratio of antibodies on nanoparticle surfaces, enabling dual-receptor synergistic targeting.
✅ Proposal of a "Programmable and Ratiometrically-Controllable" design concept for immunomodulatory nanoparticles (PRIME NP), providing a versatile framework for multifunctional nanosystems.
✅ Achievement of efficient, selective intervention of specific immune cell subsets in complex physiological environments, overcoming the limitations of traditional passive delivery.

🔹 (3) Material Development:
Poly(lactic-co-glycolic acid) (PLGA) was used as the nanoparticle core, combined with DNA molecules as structural scaffolds, to site-specifically anchor two specific antibodies (targeting DEC205 and Clec9A) onto the surface. The DNA scaffold not only provides high-precision spatial control but also enhances the uniformity and stability of ligand arrangement, allowing the nanoparticles to exhibit excellent targeting consistency and biodistribution characteristics in vivo.

🔹 (4) Broader Implications:
This work opens a new path for the "rational design" of functionalized nanosystems—transitioning from random modification to programmable construction. Future applications could extend to other cell types or multiple receptor combinations, advancing the development of multi-dimensional cellular intervention strategies. Furthermore, the DNA-mediated modular assembly offers a scalable technical pathway for intelligent responsive nanosystems.

🔹 (5) English Title:
Dual-receptor targeting of type I dendritic cells with DNA-scaffolded nanoparticles enhances STING-licensed antitumor immunity

🔹 (6) Journal Name:
Science Advances (IF 12.5)

📌 This content is for academic exchange and research sharing purposes only, and is provided for readers' reference and discussion.
#Nanotechnology #DNA #ResearchLife #ResearchSharing #Nanomaterials #Immunomodulation #BiomedicalEngineering #Biomaterials #ScientificResearch #BioengineeringCrossover

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1 week ago | [YT] | 1

Nanomedicine and Nanomaterial Customization

Bimetallic MOF Hydrogel with IF 19 Reshapes Bone Microenvironment

📍 Overview
This study addresses the challenges posed by microenvironmental barriers in large‑size bone defect repair. Under complex physiological conditions, persistent inflammatory responses, elevated oxidative stress, and insufficient vascularization collectively restrict the functionality of bone marrow mesenchymal stem cells (BMSCs), impairing tissue regeneration. To tackle this challenge, the researchers developed a novel composite hydrogel scaffold system that enables multi‑factor synergistic regulation of the local microenvironment, effectively guiding cellular behavior and significantly promoting the reconstruction and integration of bone structure.

💡 Innovation
The core breakthrough of this work lies in the integrated design combining immunomodulation, angiogenesis, and stem‑cell fate regulation. Unlike traditional single‑function materials, this hydrogel not only regulates macrophage phenotype switching but also enables sustained release of functional ions and stable delivery of active molecules, forming a dynamic support network that promotes tissue regeneration from multiple biological perspectives, demonstrating highly integrated functional advantages.

🧪 Material Development
The study employed a bimetallic MOF (ZnCo‑MOF) as a nanocarrier to load the naturally‑derived astaxanthin (AST), which was then compounded with a hydrogel matrix to form a three‑dimensional scaffold. The system exhibits good biocompatibility and controllable release properties, maintaining astaxanthin bioactivity over extended periods while achieving progressive release of Zn²⁺/Co²⁺ ions, thereby locally constructing a microenvironment conducive to regeneration. The material structure combines mechanical stability with bioactive responsiveness, making it suitable for morphological adaptation and long‑term functional support in complex defect areas.

🔍 Mechanistic Insight
At the mechanistic level, the study revealed a novel intracellular action pathway of astaxanthin: it specifically localizes to the endoplasmic reticulum, binds to HSP90 protein, and subsequently activates the IRE1α‑XBP1 signaling axis of the unfolded protein response. Activation of this pathway ultimately upregulates the expression of the key osteogenic transcription factor Osterix, thereby driving BMSC differentiation toward osteogenesis while inhibiting adipogenic differentiation. Moreover, a synergistic effect exists between the metal ions and astaxanthin, further enhancing cell proliferation and tissue regeneration potential.

📘 English Title
Bimetallic MOF‑Incorporated Hydrogel Scaffolds for Astaxanthin Delivery: Remodeling Bone Microenvironment and Accelerating Bone Repair

📚 Journal
Advanced Functional Materials (IF: 19)

📢 This post is intended for academic exchange and research sharing only. Content is for reference and discussion purposes.
#Biomaterials #RegenerativeMedicine #Nanocarrier #SignalingPathway #StemCellDifferentiation #ResearchUpdate #ScienceSharing #MaterialsScience #StemCellResearch #BoneRegeneration

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