Nanomedicine and Nanomaterial Customization

Advanced Materials | Calcium Shuttling Nanoagonist Reprograms Anti-Tumor Immunity

(1) Journal Source
Advanced Materials (IF 26.8)

(2) Title
Sustained Endogenous Calcium Shuttling via ER‑Mitochondria Crosstalk Generates Potent Anti‑Tumor Immunity

(3) Research Insight
To achieve precise manipulation of intracellular calcium homeostasis, this study proposes an organelle crosstalk paradigm. By harnessing innate calcium dynamics to drive calcium vortex‑mediated anti‑tumor immunity, it overcomes the limitations of traditional exogenous calcium‑dependent strategies, enabling customizable subcellular bioenergetic perturbation without systemic toxicity.

(4) Key Innovations
🔬 First ER‑Mitochondria Calcium Shuttling Mechanism: Triggers endogenous calcium flux to remodel the tumor immune microenvironment.
⚡ Beyond Exogenous Calcium Dependency: Achieves safe and precise intracellular ion manipulation.
🔄 Modular Nanoagonist Design: Enables ultrasound‑responsive controllable activation.

(5) Material Development & Validation
🧪 Material: Modular peptide‑programmed nanoagonist. Under ultrasound irradiation, it induces ER stress and opens mitochondrial calcium uniporters, activating calcium enrichment and calcium‑sensitive organelle calcium influx. Dual organelle‑targeted dysfunction activates caspase‑dependent apoptotic pathways, releasing damage‑associated molecular patterns (DAMPs), promoting dendritic cell maturation and cytotoxic T cell infiltration, while simultaneously reprogramming macrophages. In tumor models, it achieves primary tumor ablation and metastatic growth suppression.

(6) Research Implications
💡 Inverse Thinking: Moves beyond exogenous calcium supplementation by targeting endogenous calcium homeostasis, opening a new direction for immunotherapy.
🔗 Systematic Integration: Combines organelle crosstalk, ion regulation, and immune activation for multi‑mechanism synergistic anti‑tumor effects.
🚀 Platform Potential: This transferable strategy provides a new paradigm for ion‑regulation‑based immunotherapy.

🛎️ Suggested Hashtags
#CancerImmunotherapy #CalciumSignaling #OrganelleCrosstalk #Nanoagonist #AdvancedMaterials #UltrasoundResponsive #ERMitochondria #ImmuneReprogramming #Nanomedicine #DrugDelivery

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1 hour ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Nature Communications | Biomimetic Nanodisc Selectively Activates Non‑Canonical STING Pathway for Cancer Immunotherapy

(1) Journal Source
Nature Communications

(2) Title
A biomimetic nanodisc system selectively activates type I interferons by nonclassical STING pathway for cancer immunotherapy

(3) Research Insight
To address low STING expression in tumor cells and impaired endoplasmic reticulum‑Golgi trafficking, a cell‑membrane‑biomimetic nanodisc system is constructed to selectively activate type I interferons via a non‑canonical pathway.

(4) Key Innovations
🔬 Bypassing ER/Golgi: Directly activates the STING‑IRF3‑IFN axis in the cytosol without triggering NF‑κB‑driven inflammatory signals, thereby remodeling the tumor immune microenvironment.

(5) Material Development & Validation
🧪 Material: STING‑overexpressing membrane fragments prepared by membrane display technology, self‑assembled into nanodiscs and co‑loaded with cGAMP and heparin.
⚙️ Function: Enables stable intracellular activation and tumor‑targeted enrichment.

(6) Research Implications
💡 Inverse Thinking: Establishes a new paradigm of direct cytosolic activation, overcoming classical trafficking dependency.
🔗 Systematic Integration: Forms a closed‑loop chain from material assembly to site‑specific activation and immune regulation.
🚀 Platform Potential: Offers a universal immunotherapeutic strategy for STING‑deficient tumors.

🛎️ Suggested Hashtags
#CancerImmunotherapy #STING #Biomimetic #Nanodisc #TypeIInterferon #NatureCommunications #DrugDelivery #TumorMicroenvironment #NonCanonical #Nanomedicine

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1 day ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Bioactive Materials | Plant Exosome Hydrogel Regulates Macrophage Efferocytosis to Heal Diabetic Wounds

(1) Journal Source
Bioactive Materials

(2) Title
Activating the cellular scavenger: A bioactive hydrogel promotes diabetic wounds via plant exosome-like nanovesicles enhanced macrophage efferocytosis

(3) Research Insight
Diabetic ulcer repair is persistently hindered by immune microenvironment dysregulation, among which impaired macrophage clearance of apoptotic cell debris (efferocytosis) represents a core bottleneck leading to prolonged inflammation. Existing exosome therapies predominantly rely on animal‑derived cell cultures, facing challenges of scalability and stability. Plant‑derived nanovesicles (G-ELNs) have emerged as promising alternatives due to their inherent immunomodulatory potential, high yield, and low cost. However, their efferocytosis regulatory mechanisms in chronic wounds remain unclear, and suitable local sustained‑release carriers are lacking.

(4) Research Approach
This study extracts G-ELNs from grape pulp. Using transcriptomics, it identifies the key target MERTK and confirms that G-ELNs activate this receptor to drive macrophage polarization toward the reparative M2c phenotype, enhancing efferocytosis efficiency by over 90%. To overcome enzymatic degradation, G-ELNs are loaded into a photocrosslinked decellularized matrix hydrogel (SM). Leveraging its microporous topology and controlled degradation, spatiotemporally targeted delivery is achieved. In a diabetic rat full‑thickness defect model, this system preferentially activates MERTK‑dependent efferocytosis during the inflammatory phase to block the inflammatory cascade, while promoting orderly collagen crosslinking and vascular network maturation during the proliferative phase.

(5) Key Innovations
🔬 First Combination of Plant‑Derived Nanovesicles with Matrix Hydrogel: Establishes a dual‑regulation “metabolite‑driven” paradigm for chronic wound immune modulation.
⚙️ Novel Mechanism Beyond miRNA: Reveals that L‑malic acid in G-ELNs synergistically enhances M2c polarization and efferocytosis via the GPR4‑STAT3 axis, offering a new target for natural product‑mediated immune remodeling.
🔄 Precision Delivery System: The photocrosslinking properties and synchronized degradation profile of the hydrogel enhance delivery precision, demonstrating favorable clinical translational potential.

(6) Material Development & Validation
🧪 Material: G-ELNs derived from grape pulp; photocrosslinked decellularized matrix hydrogel (SM) as delivery carrier.
⚙️ Function:

G-ELNs activate MERTK, driving M2c macrophage polarization and enhancing efferocytosis efficiency by >90%.

SM hydrogel enables spatiotemporal targeted delivery via microporous topology and controlled degradation.

Validated in diabetic rat full‑thickness defect models: blocks inflammatory cascade in early phase, promotes orderly collagen crosslinking and vascular maturation in proliferative phase.

(7) Research Implications
💡 Plant‑Derived Alternative: Offers a scalable, low‑cost alternative to animal‑derived exosomes with distinct mechanistic advantages.
🔗 Metabolite‑Driven Immunomodulation: Uncovers L‑malic acid/GPR4‑STAT3 axis as a novel pathway for macrophage reprogramming, expanding the scope of natural product‑mediated immune regulation.
🚀 Translational Potential: The photocrosslinked hydrogel platform combines precision delivery with clinical practicality, providing a versatile strategy for chronic wound management.

🛎️ Suggested Hashtags
#DiabeticUlcer #PlantExosomes #Macrophage #Efferocytosis #Hydrogel #BioactiveMaterials #WoundHealing #Immunomodulation #ChronicWounds #TranslationalMedicine

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5 days ago | [YT] | 1

Nanomedicine and Nanomaterial Customization

Biomaterials | Liver-Targeting Fluorescent Nanomedicine: A New Approach for Non-Alcoholic Fatty Liver Disease

(1) Journal Source
Biomaterials (IF 12.9)

(2) Title
A Liver-Targeting Fluorescent Nanomedicine for the Treatment of Non-Alcoholic Fatty Liver Disease

(3) Research Insight
Non-alcoholic fatty liver disease (NAFLD) is characterized by abnormal hepatic lipid accumulation. This study develops a nanomedicine, LIGHT, which possesses liver-targeting properties, intrinsic fluorescence, and high affinity for intracellular lipid droplets. Following intravenous administration, LIGHT accumulates in the liver, reduces lipid deposition in steatotic cell models, enables real-time lesion monitoring in animal models, and restores liver morphology and function, offering a theranostic platform for the disease.

(4) Key Innovations
🔬 Integrated Theranostic Nanoplatform: Constructs a liver-targeting nanomedicine that combines diagnosis, therapy, and real-time efficacy monitoring into a single system, achieving “targeted image-guided therapy,” simplifying treatment workflows, and providing a novel strategy for NAFLD intervention.

(5) Material Development & Validation
🧪 Material: LIGHT nanomedicine (Lipid droplet‑Guided + Hepatic Targeting), featuring intrinsic fluorescence, liver-targeting capability, and high lipid droplet affinity.
⚙️ Validation: Functional validation conducted in free fatty acid‑induced steatotic cell models and NAFLD mouse models.

(6) Research Implications
💡 Inverse Design Thinking: Breaks the traditional separation of diagnosis and therapy, adopting an integrated approach to address disease intervention challenges.
🔗 Systematic Integration: Combines targeting, imaging, and therapeutic functions into a single platform for multi‑step协同 intervention.
🚀 Platform Potential: Offers a universal design paradigm for theranostic applications in lipid metabolism‑related diseases.

🛎️ Suggested Hashtags
#NAFLD #Nanomedicine #Theranostics #LiverDisease #LipidMetabolism #Biomaterials #FluorescentImaging #DrugDelivery #TargetedTherapy #MetabolicDisease

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6 days ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Bioactive Materials | Hydrogel Synergizes STING Inhibition and ROS Scavenging to Promote Diabetic Wound Healing

(1) Journal Source
Bioactive Materials

(2) Title
Glucose/ROS‑responsive and redox‑gated adaptive hydrogel dressing for accelerating diabetic wound repair via synergistic cGAS/STING pathway inhibition and oxidative stress alleviation

(3) Research Insight
A core pathological factor in non‑healing diabetic wounds is hyperglycemia‑induced mitochondrial oxidative stress, which leads to mtDNA leakage and sustained activation of the cGAS‑STING pathway in macrophages, driving inflammatory phase arrest. Existing dressings struggle to simultaneously conform to irregular wound shapes, maintain dynamic mechanical stability, and modulate the microenvironment. Therefore, constructing a hydrogel system that responds to dual hyperglycemia/ROS signals, targets the STING pathway, and possesses adaptive mechanical properties is a key strategy for improving the wound regenerative microenvironment.

(4) Research Approach
This study designs an SG hydrogel based on dynamic phenylboronate ester crosslinking, loaded with STING inhibitor H151 within macrophage‑targeting liposomes (HPSL). The system leverages hyperglycemia and ROS to trigger hydrogel disintegration, achieving synergistic release of chlorogenic acid for direct ROS scavenging and targeted HPSL delivery. Efficient macrophage uptake mediated by phosphatidylserine (PS) inhibits the STING‑TBK1‑IRF3 axis, driving macrophage polarization toward the M2 phenotype. This blocks the inflammatory cascade at its source, offering a precision intervention to reshape immune‑oxidative homeostasis.

(5) Key Innovations
🔬 Integrated Multifunctional Platform: Combines dynamic chemical crosslinking, microenvironment‑responsive release, and cell‑targeted delivery within a single hydrogel system, overcoming the limitations of single‑function dressings.
⚙️ Dual‑Regulation Synergy: Achieves spatiotemporal matching from inflammatory arrest to proliferative remodeling through the dual regulation of “ROS scavenging + STING pathway inhibition,” with robust data and clear mechanistic validation.

(6) Material Design & Validation
🧪 Material: SG hydrogel with dynamic phenylboronate ester crosslinks, loaded with H151‑encapsulated macrophage‑targeting liposomes (HPSL).
⚙️ Function:

High glucose and ROS trigger hydrogel disintegration for controlled release.

Chlorogenic acid provides direct ROS scavenging.

HPSL enables targeted macrophage delivery via PS‑mediated uptake.

Inhibits the STING‑TBK1‑IRF3 axis, promoting M2 macrophage polarization and blocking inflammatory cascade initiation.

(7) Research Implications
💡 Pathology‑Driven Design: Targets the upstream mitochondrial‑STING axis rather than downstream inflammation, addressing the root cause of diabetic wound healing arrest.
🔗 Systematic Integration: Seamlessly combines dynamic crosslinking chemistry, microenvironment responsiveness, and cellular targeting for coordinated therapeutic action.
🚀 Platform Potential: This design strategy can be extended to other inflammatory conditions driven by oxidative stress and STING pathway activation.

🛎️ Suggested Hashtags
#DiabeticWound #Hydrogel #STINGPathway #ROS #MacrophagePolarization #BioactiveMaterials #DrugDelivery #WoundHealing #Immunometabolism #RegenerativeMedicine

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1 week ago | [YT] | 1

Nanomedicine and Nanomaterial Customization

Chemical Engineering Journal | Tetrahedral Framework Nucleic Acid Delivers Rapamycin to Combat Stem Cell Senescence

(1) Journal Source
Chemical Engineering Journal

(2) Title
Engineering a tetrahedral framework nucleic acid-based nanomedicine for precise intracellular delivery of rapamycin to rescue senescent bone mesenchymal stem cells

(3) Research Insight
Regenerative failure in age-related osteoporosis is closely linked to inflammation-driven senescence of bone marrow mesenchymal stem cells (BMSCs). Existing interventions face challenges such as low drug bioavailability and difficulty in precise modulation of the local microenvironment. Mitochondrial dysfunction and activation of aberrant intracellular DNA sensing pathways are recognized as key upstream events in stem cell functional decline. This study addresses this mechanistic gap by exploring a precision intervention strategy based on nucleic acid nanostructures.

(4) Research Approach
The researchers leveraged the programmable properties of tetrahedral framework nucleic acids (tFNAs) to construct a rapamycin-loaded nanocomplex. Leveraging its size and geometric advantages, the system achieves efficient delivery to senescent stem cells. The study focuses on the inflammatory signaling cascade triggered by “minority mitochondrial outer membrane permeabilization” (miMOMP). By restoring mitochondrial integrity and inhibiting cGAS-STING pathway activity, it intervenes at the source of the stem cell senescence phenotype, offering a mechanism-driven engineered strategy for skeletal aging.

(5) Key Innovations & Evaluation
🔬 Integration of DNA Nanotechnology with Aging Biology: Breaks through the limitations of conventional drug delivery by combining programmable nucleic acid structures with mechanistic insights into senescence.
⚙️ Mechanistic Clarity: Elucidates the coupling between sublethal mitochondrial damage and intracellular immune responses in bone aging, targeting this axis with a precision nanoplatform.
🚀 Translational Consideration: While demonstrating efficacy, the study notes that the systemic distribution efficiency of this system within intact bone tissue requires further optimization.

(6) Research Implications
💡 Mechanism-Driven Design: Targets the upstream mitochondrial-immune axis rather than downstream inflammatory effects, offering a foundational intervention for stem cell senescence.
🔗 Programmable Nanoplatform: The tFNA-based delivery system provides a versatile scaffold for precise intracellular delivery of various therapeutics.
🚀 Future Directions: Enhanced bone-targeting strategies could further improve the translational potential of this platform for age-related skeletal disorders.

🛎️ Suggested Hashtags
#Aging #StemCells #Osteoporosis #TetrahedralDNA #Nanomedicine #Rapamycin #Mitochondria #cGASSTING #ChemicalEngineeringJournal #RegenerativeMedicine

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1 week ago | [YT] | 2

Nanomedicine and Nanomaterial Customization

Advanced Materials | Biodegradable Nanospray: A Sunlight-Activated Antibacterial Strategy

(1) Journal Source
Advanced Materials

(2) Title
Biodegradable Nanospray for Sunlight-Activated Photodynamic Antibacterial Therapy and Wound Healing

(3) Research Insight
The rise of drug-resistant bacteria and the non-degradable nature of traditional cationic antimicrobial agents limit the clinical safety of existing skin disinfection strategies, while conventional photodynamic therapy suffers from complex application procedures. This study develops a biodegradable, sunlight-activated photodynamic cationic nanospray, providing an innovative platform for combating antibiotic-resistant bacterial infections.

(4) Key Innovations
🔬 Dual-Mechanism Antibacterial Synergy: Achieves synergistic antibacterial action combining photodynamic effects with quaternary ammonium cations. Under sunlight irradiation, it efficiently generates reactive oxygen species (ROS) while leveraging cationic interactions to enhance antibacterial efficacy, significantly reducing inflammation in the infected microenvironment and accelerating wound healing in drug-resistant bacterial infections.
⚡ Biodegradability Breakthrough: Overcomes the non-degradable limitations of traditional antimicrobial agents, enhancing clinical safety.

(5) Material Development & Validation
🧪 Material: Biodegradable nanospray carrier (NpPORPMn) designed and synthesized for efficient ROS generation under sunlight irradiation.
⚙️ Validation: Skin disinfection experiments confirm the system’s efficacy in clearing pathogenic bacteria and resident microbial communities from the skin surface, while maintaining excellent biodegradability and biocompatibility.

(6) Research Implications
💡 Inverse Design Thinking: Shifts focus from traditional antimicrobial frameworks to address core shortcomings through “biodegradability” and “convenient light activation,” offering new perspectives for antimicrobial material design.
🔗 Systematic Integration: Integrates photodynamic activity, cationic antibacterial properties, and biodegradability into a single nanospray system, achieving multi-mechanism synergy and functional complementarity.
🚀 Platform Potential: This nanospray platform can be adapted to different infection scenarios by adjusting functional components, providing a modular solution for diverse antimicrobial needs.

🛎️ Suggested Hashtags
#Antibacterial #PhotodynamicTherapy #Biodegradable #Nanospray #DrugResistance #WoundHealing #AdvancedMaterials #SunlightActivated #CationicAntimicrobial #InfectiousDisease

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1 week ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Biomaterials | Aspirin-Primed Extracellular Vesicles Modulate Macrophages to Enhance Osteochondral Regeneration

(1) Journal Source
Biomaterials

(2) Title
Aspirin-Induced Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Osteochondral Regeneration by Reprogramming Macrophages

(3) Research Insight
Osteochondral injury triggers a robust local inflammatory response dominated by M1 macrophages, which severely suppresses endogenous stem cell function and leads to failed hyaline cartilage repair. Existing interventions struggle to balance immunomodulation with structural reconstruction. Aspirin, a classic anti-inflammatory drug, faces limitations in intra-articular application due to its short half-life and systemic toxicity. This study leverages the natural regulatory capacity of stem cell-derived extracellular vesicles combined with aspirin preconditioning to construct a novel repair platform targeting the inflammatory metabolic axis.

(4) Key Innovations
🔬 Aspirin-Primed Functional EVs: Obtains functionally enhanced extracellular vesicles (Asp-EVs) by preconditioning bone marrow mesenchymal stem cells (BMSCs) with aspirin.
⚙️ Mechanistic Elucidation: Identifies the molecular mechanism by which Asp-EVs activate macrophage mitophagy via the PINK1/Parkin pathway, shifting metabolism from glycolysis toward oxidative phosphorylation.
🔄 Hybrid Hydrogel Delivery System: Designs a thermoresponsive hydrogel incorporating polyhedral oligomeric silsesquioxane (POSS) as a delivery carrier. The organic‑inorganic hybrid structure enhances mechanical properties and enables sustained intra‑articular release, synergistically regulating the regenerative microenvironment at the immunometabolic level.

(5) Material Development & Validation
🧪 Material: Aspirin-primed BMSC-derived extracellular vesicles (Asp-EVs); POSS-based thermoresponsive hydrogel delivery system.
⚙️ Functions:

Asp-EVs reprogram macrophage polarization via PINK1/Parkin-mediated mitophagy, promoting metabolic shift from glycolysis to oxidative phosphorylation.

POSS hydrogel provides enhanced mechanical properties and sustained release of Asp-EVs in the joint cavity.

Demonstrated efficacy in promoting osteochondral regeneration through coordinated immunometabolic regulation.

(6) Research Implications
💡 Drug-EVs Synergy: Integrates drug preconditioning with the natural regulatory capabilities of extracellular vesicles, establishing a novel paradigm for enhancing EV functionality.
🔗 Immunometabolic Targeting: Reveals a previously unexplored mechanism of macrophage reprogramming via mitochondrial quality control, offering a new intervention strategy for inflammation-driven tissue damage.
🚀 Platform Potential: The POSS-based hybrid hydrogel provides a versatile delivery platform for bioactive agents requiring sustained local release, applicable to various orthopedic and regenerative medicine contexts.

🛎️ Suggested Hashtags
#OsteochondralRegeneration #ExtracellularVesicles #Aspirin #MacrophageReprogramming #Mitophagy #Biomaterials #Immunometabolism #Hydrogel #StemCells #TissueEngineering

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1 week ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Bioactive Materials | Intelligent Responsive Hydrogel Accelerates Diabetic Foot Ulcer Repair

(1) Journal Source
Bioactive Materials (IF 20.3)

(2) Title
Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair

(3) Research Insight
Diabetic foot ulcer healing is hindered by multiple obstacles, including immune microenvironment dysregulation, infection, and insufficient angiogenesis. Existing dressings fail to achieve systematic regulation. This study proposes an “intelligent response‑synergistic regulation” strategy, designing a multifunctional hydrogel dressing that enables precise sensing of the wound microenvironment and multi‑pathway repair.

(4) Key Innovations
🔬 Multi‑Target Synergistic Cascade: Moves beyond single‑target intervention by constructing a synergistic cascade integrating immune remodeling, antibacterial activity, and angiogenesis, enabling dynamic response to the complex pathological microenvironment and systematic repair.

(5) Material Development & Validation
🧪 Material: Deferoxamine‑loaded manganese‑doped zeolitic imidazolate framework (Mn‑ZIF@DFO) with dual enzyme‑mimetic activity for ROS scavenging; glucose and ROS‑responsive chitosan hydrogel loaded with the above nanomaterial and exosomes.
⚙️ Function: In infection models, the system achieves synergistic bacterial clearance, immune reconstruction, and angiogenesis promotion.

(6) Research Implications
💡 Pathology‑Driven Design: Moves from static intervention to dynamic response by designing responsive materials based on pathological microenvironment characteristics.
🔗 Systematic Integration: Integrates multiple functional modules to achieve synergistic regulation of immune response, antibacterial activity, and angiogenesis.
🚀 Platform Potential: Offers a universal design paradigm for intelligent biomaterials targeting complex pathological microenvironments.

🛎️ Suggested Hashtags
#DiabeticFootUlcer #SmartHydrogel #WoundHealing #Immunomodulation #Angiogenesis #BioactiveMaterials #DrugDelivery #ROSResponsive #Exosomes #RegenerativeMedicine

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2 weeks ago | [YT] | 1

Nanomedicine and Nanomaterial Customization

Advanced Science | Fenbendazole + Photothermal Therapy: A New Immunotherapy Strategy for Bladder Cancer

(1) Journal Source
Advanced Science (IF 14.1)

(2) Title
Fenbendazole-Induced Ferroptosis Combined with Photothermal Therapy Triggers Dual Immunotherapy for Bladder Cancer

(3) Research Insight
This study designs a novel intravesical nanoplatform that integrates ferroptosis‑associated oxidative damage, immunogenic cell death (ICD) activation, and photothermal therapy for synergistic bladder cancer treatment. Via transurethral intravesical administration, the platform achieves sustained drug release and localized photothermal effects while inducing key ICD markers, promoting dendritic cell maturation and T‑cell activation, ultimately exerting anti‑tumor activity.

(4) Key Innovations
🔬 First Combination of Fenbendazole‑Induced Ferroptosis with Photothermal Therapy: Constructs an intravesical nanodelivery system for synergistic bladder cancer treatment.
⚡ Localized Delivery & Immune Activation: Enables transurethral administration with sustained drug release and photothermal response, simultaneously activating immune responses to enhance anti‑tumor efficacy.

(5) Material Development
🧪 Material: FBZ@BSA@PDA nanoplatform (fenbendazole, bovine serum albumin, polydopamine).
⚙️ Functions:

BSA serves as an efficient encapsulation carrier for fenbendazole loading.

PDA is formed via in situ polymerization, enhancing tissue adhesion and photothermal responsiveness.

The platform induces ferroptosis hallmarks (lipid peroxidation, GSH depletion) while activating immunogenic cell death, triggering robust anti‑tumor immune responses.

(6) Research Implications
💡 Synergistic Therapeutic Design: Couples ferroptosis induction with photothermal therapy for dual‑mechanism anti‑tumor efficacy.
🔗 Localized Immunotherapy: Intravesical administration enables sustained local drug release and immune activation, minimizing systemic exposure.
🚀 Platform Potential: This strategy can be extended to other superficial tumors amenable to local therapy, offering a versatile approach for combination immunotherapy.

🛎️ Suggested Hashtags
#BladderCancer #Fenbendazole #PhotothermalTherapy #Ferroptosis #Immunotherapy #AdvancedScience #Nanomedicine #DrugDelivery #ImmunogenicCellDeath #CancerResearch

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2 weeks ago | [YT] | 1