Nanomedicine and Nanomaterial Customization

AFM | Bone-Targeting Cellular Backpacks for Precise Intervention in Bone Diseases ✨

(1) Journal Source
Advanced Functional Materials

(2) Title
Bone‑Homing Cellular Backpacks Integrating Metabolic Intervention and Synergistic Osteogenesis to Treat Bone Metastasis and Promote Diabetic Bone Repair

(3) Research Insight
Abnormal osteoclast activity is a core pathological feature of bone metastasis and metabolic bone diseases, yet existing intervention strategies have limitations. This study utilizes mesenchymal stem cells (MSCs) as carriers to construct a bone‑homing cellular backpack platform that integrates metabolic intervention and synergistic osteogenic functions, aiming to precisely regulate pathological processes within the bone microenvironment.

(4) Key Innovations
🎯 First Multifunctional Backpack System: The first to integrate metabolic intervention, osteoclast‑tumor regulation, and bone regeneration within a single cellular backpack system.
🦴 Dual‑Action Bone Microenvironment Regulation: Utilizes lipid‑coated nanoparticles loaded with a metabolic inhibitor combined with calcium‑based mineralization to precisely inhibit osteoclast activity. Simultaneously, leverages the homing ability of MSCs to synergistically promote osteogenic differentiation, achieving bidirectional regulation of the bone microenvironment.

(5) Material Development
🧪 Platform Design: A bio‑hybrid cellular backpack constructed on an MSC base, loaded with lipid‑coated nanoparticles encapsulating a phosphoglycerate dehydrogenase inhibitor and enriched with calcium ions via mineralization.
⚙️ Function & Validation:

Relies on CXCR4‑mediated homing to target osteoclast‑ and tumor‑rich bone microenvironments.

Validated in animal models to inhibit bone resorption, limit tumor progression, and accelerate bone repair.

(6) Research Implications
💡 Pathology‑Driven Strategy: Adopts a reverse‑engineering approach from the mechanism of bone metabolic imbalance, designing a bidirectional “inhibit abnormality + activate repair” strategy that surpasses single‑intervention limitations.
🔬 Integrated Multiscale System: Combines cell carrier, targeted delivery, metabolic intervention, and regenerative repair into a multidimensional intervention system from molecule to tissue.
🚀 Versatile Platform: This cellular backpack platform can be extended to other metabolic bone diseases or bone injury scenarios, providing a universal technical framework for bone microenvironment regulation.

#BoneMetastasis #CellularBackpack #MesenchymalStemCells #BoneRegeneration #MetabolicIntervention #Osteoclast #AdvancedFunctionalMaterials #TargetedTherapy #DiabeticBoneRepair #Orthopedics

Skip the Carousel

1 2 3 4 5 6 7 8

13 hours ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

AFM | Bone-Targeting Cellular Backpacks for Precise Intervention in Bone Diseases ✨

(1) Journal Source
Advanced Functional Materials

(2) Title
Bone‑Homing Cellular Backpacks Integrating Metabolic Intervention and Synergistic Osteogenesis to Treat Bone Metastasis and Promote Diabetic Bone Repair

(3) Research Insight
Abnormal osteoclast activity is a core pathological feature of bone metastasis and metabolic bone diseases, yet existing intervention strategies have limitations. This study utilizes mesenchymal stem cells (MSCs) as carriers to construct a bone‑homing cellular backpack platform that integrates metabolic intervention and synergistic osteogenic functions, aiming to precisely regulate pathological processes within the bone microenvironment.

(4) Key Innovations
🎯 First Multifunctional Backpack System: The first to integrate metabolic intervention, osteoclast‑tumor regulation, and bone regeneration within a single cellular backpack system.
🦴 Dual‑Action Bone Microenvironment Regulation: Utilizes lipid‑coated nanoparticles loaded with a metabolic inhibitor combined with calcium‑based mineralization to precisely inhibit osteoclast activity. Simultaneously, leverages the homing ability of MSCs to synergistically promote osteogenic differentiation, achieving bidirectional regulation of the bone microenvironment.

(5) Material Development
🧪 Platform Design: A bio‑hybrid cellular backpack constructed on an MSC base, loaded with lipid‑coated nanoparticles encapsulating a phosphoglycerate dehydrogenase inhibitor and enriched with calcium ions via mineralization.
⚙️ Function & Validation:

Relies on CXCR4‑mediated homing to target osteoclast‑ and tumor‑rich bone microenvironments.

Validated in animal models to inhibit bone resorption, limit tumor progression, and accelerate bone repair.

(6) Research Implications
💡 Pathology‑Driven Strategy: Adopts a reverse‑engineering approach from the mechanism of bone metabolic imbalance, designing a bidirectional “inhibit abnormality + activate repair” strategy that surpasses single‑intervention limitations.
🔬 Integrated Multiscale System: Combines cell carrier, targeted delivery, metabolic intervention, and regenerative repair into a multidimensional intervention system from molecule to tissue.
🚀 Versatile Platform: This cellular backpack platform can be extended to other metabolic bone diseases or bone injury scenarios, providing a universal technical framework for bone microenvironment regulation.

#BoneMetastasis #CellularBackpack #MesenchymalStemCells #BoneRegeneration #MetabolicIntervention #Osteoclast #AdvancedFunctionalMaterials #TargetedTherapy #DiabeticBoneRepair #Orthopedics

Skip the Carousel

1 2 3 4 5 6 7 8

13 hours ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

AFM | Bone-Targeting Cellular Backpacks for Precise Intervention in Bone Diseases ✨

(1) Journal Source
Advanced Functional Materials

(2) Title
Bone‑Homing Cellular Backpacks Integrating Metabolic Intervention and Synergistic Osteogenesis to Treat Bone Metastasis and Promote Diabetic Bone Repair

(3) Research Insight
Abnormal osteoclast activity is a core pathological feature of bone metastasis and metabolic bone diseases, yet existing intervention strategies have limitations. This study utilizes mesenchymal stem cells (MSCs) as carriers to construct a bone‑homing cellular backpack platform that integrates metabolic intervention and synergistic osteogenic functions, aiming to precisely regulate pathological processes within the bone microenvironment.

(4) Key Innovations
🎯 First Multifunctional Backpack System: The first to integrate metabolic intervention, osteoclast‑tumor regulation, and bone regeneration within a single cellular backpack system.
🦴 Dual‑Action Bone Microenvironment Regulation: Utilizes lipid‑coated nanoparticles loaded with a metabolic inhibitor combined with calcium‑based mineralization to precisely inhibit osteoclast activity. Simultaneously, leverages the homing ability of MSCs to synergistically promote osteogenic differentiation, achieving bidirectional regulation of the bone microenvironment.

(5) Material Development
🧪 Platform Design: A bio‑hybrid cellular backpack constructed on an MSC base, loaded with lipid‑coated nanoparticles encapsulating a phosphoglycerate dehydrogenase inhibitor and enriched with calcium ions via mineralization.
⚙️ Function & Validation:

Relies on CXCR4‑mediated homing to target osteoclast‑ and tumor‑rich bone microenvironments.

Validated in animal models to inhibit bone resorption, limit tumor progression, and accelerate bone repair.

(6) Research Implications
💡 Pathology‑Driven Strategy: Adopts a reverse‑engineering approach from the mechanism of bone metabolic imbalance, designing a bidirectional “inhibit abnormality + activate repair” strategy that surpasses single‑intervention limitations.
🔬 Integrated Multiscale System: Combines cell carrier, targeted delivery, metabolic intervention, and regenerative repair into a multidimensional intervention system from molecule to tissue.
🚀 Versatile Platform: This cellular backpack platform can be extended to other metabolic bone diseases or bone injury scenarios, providing a universal technical framework for bone microenvironment regulation.

#BoneMetastasis #CellularBackpack #MesenchymalStemCells #BoneRegeneration #MetabolicIntervention #Osteoclast #AdvancedFunctionalMaterials #TargetedTherapy #DiabeticBoneRepair #Orthopedics

Skip the Carousel

1 2 3 4 5 6 7 8

13 hours ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

AFM | Bone-Targeting Cellular Backpacks for Precise Intervention in Bone Diseases ✨

(1) Journal Source
Advanced Functional Materials

(2) Title
Bone‑Homing Cellular Backpacks Integrating Metabolic Intervention and Synergistic Osteogenesis to Treat Bone Metastasis and Promote Diabetic Bone Repair

(3) Research Insight
Abnormal osteoclast activity is a core pathological feature of bone metastasis and metabolic bone diseases, yet existing intervention strategies have limitations. This study utilizes mesenchymal stem cells (MSCs) as carriers to construct a bone‑homing cellular backpack platform that integrates metabolic intervention and synergistic osteogenic functions, aiming to precisely regulate pathological processes within the bone microenvironment.

(4) Key Innovations
🎯 First Multifunctional Backpack System: The first to integrate metabolic intervention, osteoclast‑tumor regulation, and bone regeneration within a single cellular backpack system.
🦴 Dual‑Action Bone Microenvironment Regulation: Utilizes lipid‑coated nanoparticles loaded with a metabolic inhibitor combined with calcium‑based mineralization to precisely inhibit osteoclast activity. Simultaneously, leverages the homing ability of MSCs to synergistically promote osteogenic differentiation, achieving bidirectional regulation of the bone microenvironment.

(5) Material Development
🧪 Platform Design: A bio‑hybrid cellular backpack constructed on an MSC base, loaded with lipid‑coated nanoparticles encapsulating a phosphoglycerate dehydrogenase inhibitor and enriched with calcium ions via mineralization.
⚙️ Function & Validation:

Relies on CXCR4‑mediated homing to target osteoclast‑ and tumor‑rich bone microenvironments.

Validated in animal models to inhibit bone resorption, limit tumor progression, and accelerate bone repair.

(6) Research Implications
💡 Pathology‑Driven Strategy: Adopts a reverse‑engineering approach from the mechanism of bone metabolic imbalance, designing a bidirectional “inhibit abnormality + activate repair” strategy that surpasses single‑intervention limitations.
🔬 Integrated Multiscale System: Combines cell carrier, targeted delivery, metabolic intervention, and regenerative repair into a multidimensional intervention system from molecule to tissue.
🚀 Versatile Platform: This cellular backpack platform can be extended to other metabolic bone diseases or bone injury scenarios, providing a universal technical framework for bone microenvironment regulation.

#BoneMetastasis #CellularBackpack #MesenchymalStemCells #BoneRegeneration #MetabolicIntervention #Osteoclast #AdvancedFunctionalMaterials #TargetedTherapy #DiabeticBoneRepair #Orthopedics

Skip the Carousel

1 2 3 4 5 6 7 8

13 hours ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

IF=53! Sichuan University in China Achieves New Breakthrough in Combined Therapy for Liver Cancer

(1) Journal Source
Signal Transduction and Targeted Therapy
(2) Title
Lenvatinib plus transarterial chemoembolization and PD‑1 inhibitors as conversion therapies for unresectable intermediate‑advanced hepatocellular carcinoma: a phase 2 trial and exploratory biomolecular study
(3) Research Insight
This study addresses the therapeutic challenge of unresectable intermediate‑advanced hepatocellular carcinoma. To fill the evidence gap in existing treatments, it designed a prospective multicenter phase II clinical trial. Patients were divided into two groups: one receiving a combination of lenvatinib, transarterial chemoembolization (TACE), and a PD‑1 inhibitor, and the other receiving TACE alone. The aim was to compare the efficacy and safety of these different therapeutic strategies.
(4) Key Innovations
🎯 Superior Clinical Efficacy: Confirmed that the combination therapy regimen performed better on key efficacy endpoints, significantly improving patient survival benefit with an overall manageable safety profile.
🔬 Mechanistic Exploration: Through exploratory biomarker analysis using single‑cell sequencing and flow cytometry, the study revealed the correlation between specific immune cell subsets and treatment response, preliminarily elucidating the potential anti‑tumor mechanisms of the combination regimen.
(5) Key Study Design & Validation
🧪 Prospective Multicenter Trial: Employed a rigorous prospective, multicenter clinical trial design with long‑term follow‑up of enrolled patients.
⚙️ Integrated Biomarker Analysis: Beyond efficacy validation, the study analyzed immune cells in patient peripheral blood using single‑cell sequencing and flow cytometry, verifying the correlation between specific immune cell subsets and treatment outcomes, providing critical evidence for subsequent mechanistic exploration.
(6) Research Implications
💡 Clinical Problem‑Driven Approach: Started from the pain points in clinical treatment, exploring new therapeutic potential by combining existing therapies to break the limitations of single‑modality treatments.
🔄 Integrated Study Design: Deeply integrated clinical trials with biomarker analysis, validating efficacy while simultaneously exploring mechanisms, forming a complete research closed loop.
🚀 Framework Potential: This research framework for combination therapy provides a transferable paradigm for exploring immuno‑combination therapies in other solid tumors.
#LiverCancer #HCC #Immunotherapy #CombinationTherapy #Lenvatinib #TACE #PD1 #ClinicalTrial #STTT #ConversionTherapy

Skip the Carousel

1 2 3 4 5

2 days ago | [YT] | 1

Nanomedicine and Nanomaterial Customization

Nano‑Probiotic Biohybrid for Precision Modulation of Food Allergy

(1) Journal Source
ACS Nano

(2) Title
Cellular Nanoparticle‑Probiotic Biohybrid Complex for Multimodal Oral Food Allergy Therapy

(3) Research Insight
Food allergy is caused by abnormal immune responses, and current treatments have significant limitations. This study constructs a novel biohybrid system for targeted oral intervention in food allergy, systematically exploring its efficacy and safety from material design to validation in animal models.

(4) Key Innovations
🔬 First Biohybrid Design: Combines macrophage‑membrane‑derived nanoparticles with probiotics to create an orally deliverable biohybrid system.
🔄 Multimodal Synergy: Integrates enzymatic allergen degradation, probiotic‑mediated gut modulation, and nanoparticle‑enabled targeting for multi‑mechanistic regulation of allergic responses.

(5) Material Development
🧪 Material: Macrophage‑membrane‑coated nanoparticles conjugated with probiotics via click chemistry and loaded with allergen‑degrading enzymes.
⚙️ Function & Validation:

In vitro: Binds inflammatory cytokines and efficiently degrades allergens.

In vivo (food‑allergy mouse model): Oral administration suppresses inflammatory factors, restores gut microbiota diversity, alleviates allergic symptoms, and shows no significant toxicity.

(6) Research Implications
💡 Paradigm Shift: Moves from passive symptom relief to active immune regulation and gut repair through biohybrid design.
🔗 Integrated System: Combines carrier targeting, probiotic colonization, and enzymatic degradation into a complete regulatory chain from delivery to action.
🚀 Platform Potential: This biohybrid strategy can be extended to other immune‑related gut disorders, offering a new tool for mucosal immune modulation.
#FoodAllergy #NanoProbiotics #Immunotherapy #Biohybrid #GutHealth #OralDelivery #ACS_Nano #AllergyTreatment #Microbiome #Nanomedicine

Skip the Carousel

1 2 3 4 5 6

3 days ago | [YT] | 2

Nanomedicine and Nanomaterial Customization

AM：Chemical Luminescence-Driven Immunotherapy for Deep-Seated Tumors

(1) Journal Source
Advanced Materials

(2) Title
Chemiluminescence-Powered Immunotherapy for Deep-Seated Tumors: Subcellular Trafficking and Targeted PD-L1 Degradation to Trigger Pyroptosis

(3) Research Insight
Traditional photodynamic-driven immunogenic cell death strategies are effective only for superficial tumors, and related cancer immunotherapies often face issues of T cell exhaustion. This study addresses the challenge of treating deep-seated tumors by developing a Chemiluminescence-Powered Immunotherapy (CPIT) platform. It aims to overcome the limitations of conventional techniques and provide a new immunotherapeutic approach for deep-seated and malignant tumors.

(4) Key Innovations
🎯 Dual Subcellular Targeting: For the first time, combines PD-L1 lysosomal degradation with endoplasmic reticulum (ER) pyroptosis induction, creating a synergistic mechanism of "immune checkpoint blockade + immunogenic cell death."
🔆 Endogenous Chemiluminescence Activation: Employs a chemiluminescence resonance energy transfer (CRET) system to achieve precise ER activation in deep tumors without the need for external light, overcoming the tissue penetration limits of traditional photodynamic therapy.
🛡️ Dual-Lock Safety & Efficacy: Utilizes a dual-lock mechanism of tumor-specific delivery and activation to enhance anti-tumor effects while minimizing off-target toxicity.

(5) Material Development
🧪 Core Material: A PD-L1-targeted delivery vector loaded with a dual-lock chemiluminescence-resonance energy transfer system.
⚙️ Function:

Targets PD-L1 for lysosomal delivery and promotes its degradation.

Utilizes the tumor microenvironment's pH and H₂O₂ to trigger chemiluminescence, locally generating reactive oxygen species (ROS) in the ER to induce ER stress and pyroptosis.

(6) Future Perspectives
🚀 New Paradigm: Moves beyond the conventional "external light excitation" approach by leveraging endogenous chemiluminescence for precise activation in deep tumors, offering a novel perspective for lesion-specific therapy.
🔧 Modular Design Potential: The platform’s design can be adapted with different targeting ligands and chemiluminescent donors, holding potential for application in various tumor immunotherapy scenarios.
#NanoMedicine #InterdisciplinaryEngineering #CellExperiments #Nanozymes #Biomaterials #Nanomaterials #2DMaterials #ScientificPaper #JournalArticle #SCIJourna #PaperSubmission #MaterialsSciencePaper #NanoResearch #ScientificPublication #NSFCHotTopics #InnovativeInterdisciplinaryResearch #NanomaterialSynthesis

Skip the Carousel

1 2 3 4 5 6 7 8 9 10

5 days ago | [YT] | 2

Nanomedicine and Nanomaterial Customization

ACS Nano: Decoding Lung Cancer Cells with Microfluidic Chips

(1) Journal Source
ACS Nano

(2) Title
A Microfluidic Chip for Logic-Based Analysis of Signaling Pathways in Lung Cancer Cell-Macrophage Interactions and Drug Testing

(3) Research Insight
Intercellular signaling pathways are crucial for understanding cancer mechanisms and drug development. However, existing research often focuses on discrete molecules, lacking in-depth exploration of the logical relationships within these pathways. This study develops a microfluidic chip-based electrochemical logic analysis system, aiming to decipher the signal logic within the interaction network between lung cancer cells and macrophages, providing a new tool for cancer mechanism research and drug screening.

(4) Key Innovations
🔬 First Integrated Logic Analysis System: For the first time, integrates a microfluidic chip with electrochemical sensing and DNA logic gates to construct a system capable of visually analyzing cell interaction signaling pathways on-chip.
⚡ Comprehensive Pathway Mapping: The system can not only precisely capture the logical relationship between miRNA secreted by lung cancer cells and IL-6 secreted by macrophages but also simultaneously analyze the activation state of the downstream NF-κB signaling pathway, achieving integrated analysis from molecular interaction to pathway regulation.

(5) Material Development
🧩 Integrated System Modules: The system integrates four key functional modules: a lung cancer cell chip, a macrophage chip, a logic gate chip, and an electrochemical sensing chip.
✅ Validation & Application:

Co-culture experiments validated the system's capability for efficient capture and logical analysis of cell interaction signals.

Drug tests further demonstrated that inhibitor combinations targeting this interaction network effectively induced tumor cell apoptosis, providing strong support for mechanism validation.

(6) Research Implications
💡 Paradigm Shift: Moves beyond the traditional single-molecule research framework by focusing on "signaling pathway logic," offering a new perspective for analyzing complex biological networks.
🔄 Systematic Design: Integrates cell culture, molecular detection, logic operation, and signal output on a microfluidic platform, achieving a closed-loop from "basic research" to "applied verification."
🚀 Platform Potential: This system can be extended to study interactions within other tumor microenvironments, providing a versatile technological platform for multidimensional cancer mechanism analysis and the development of precise intervention strategies.#NanoMedicine #InterdisciplinaryEngineering #CellExperiments #Nanozymes #Biomaterials #Nanomaterials #2DMaterials #ScientificPaper #JournalArticle #SCIJourna #PaperSubmission #MaterialsSciencePaper #NanoResearch #ScientificPublication #NSFCHotTopics #InnovativeInterdisciplinaryResearch #NanomaterialSynthesis

Skip the Carousel

1 2 3 4 5

6 days ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

AM: IF 26.8!! Smart Oral Nanoplatform Precisely Targets Colitis

(1) Journal Source
Advanced Materials

(2) Title
Deconstructing the Necroptosis-Engine: An Oral Nanosponge for Targeted Therapy of Ulcerative Colitis

(3) Research Insight
Clinical treatment of ulcerative colitis has long faced challenges such as poor targeting and significant side effects. A core pathological feature is excessive necrosis of intestinal epithelial cells, which disrupts the gut barrier. Addressing this, the study constructs an oral nanoplatform integrating both diagnostic and therapeutic functions, aiming to precisely intervene in the disease progression.

(4) Key Innovations
🧠 First-of-its-kind 'Necroptosis Inhibition + Anti-inflammation' Strategy: Proposes a synergistic intervention strategy integrating diagnostic and therapeutic functions into a single nanocarrier for the first time.
🎯 Dual-functional Precision: The platform not only precisely localizes to inflammation sites but also blocks pathological processes through multiple mechanisms, offering a novel non-invasive oral strategy for treating such diseases.

(5) Material Development
🧪 Material: The nanoplatform consists of a barium sulfate core and a pH-responsive silk fibroin nanosponge carrier, co-loaded with a necrosis inhibitor and an antioxidant.
⚡ Key Functions & Validation:
• Responsive Release: The carrier remains stable in the acidic gastric environment and expands upon reaching the neutral intestine, enabling localized, precise drug release.
• Mucoadhesion: The carrier's negative charge allows electrostatic adhesion to the inflamed mucosa, prolonging its action time.
• In Vivo Efficacy: In a mouse colitis model, the platform effectively inhibited intestinal epithelial cell necrosis, alleviated oxidative stress, promoted barrier repair, and modulated gut microbiota structure, outperforming clinical first-line drugs.

(6) Research Implications
💡 Paradigm Shift: Focuses on the core pathological link of "intestinal epithelial cell necrosis" rather than just inflammatory symptoms, providing a novel targeting approach for disease intervention.
🔄 Systematic Design: Highly integrates functions like diagnostic imaging, targeted delivery, and multi-drug synergy, achieving a "diagnosis-treatment-evaluation" closed-loop management.
🚀 Platform Versatility: The pH-responsive nanosponge carrier has universal applicability and can be loaded with different drugs for treating other intestinal diseases.
#NanoMedicine #InterdisciplinaryEngineering #CellExperiments #Nanozymes #Biomaterials #Nanomaterials #2DMaterials #ScientificPaper #JournalArticle #SCIJourna #PaperSubmission #MaterialsSciencePaper #NanoResearch #ScientificPublication #NSFCHotTopics #InnovativeInterdisciplinaryResearch #NanomaterialSynthesis

Skip the Carousel

1 2 3 4 5 6 7 8 9 10

1 week ago | [YT] | 1

Nanomedicine and Nanomaterial Customization

🔥 Photothermal-Driven Strategy for Synergistic Osteoarthritis Regeneration

(1) Journal Source
Advanced Functional Materials

(2) Title
Photothermal‑Driven Spatiotemporal Delivery of Bioactive Facilitators for Coordinated Cartilage and Subchondral Bone Regeneration in Osteoarthritis

(3) Research Insight
Osteoarthritis (OA) is a complex degenerative disease characterized by cartilage erosion, subchondral bone remodeling, and persistent inflammation, for which current interventions remain inadequate. This study constructs a photothermal‑driven spatiotemporal delivery nanozyme system (CPMP). By integrating antioxidant, immunomodulatory, and regenerative functions, it achieves coordinated regeneration of both cartilage and subchondral bone, offering a novel intervention strategy for OA and related inflammatory diseases.

(4) Key Innovations
🔬 First Multifunctional Nanozyme: Integrates photothermal response, reactive oxygen species (ROS) scavenging, and controlled release of bioactive factors into one system, enabling spatiotemporal and synergistic regulation of both cartilage and subchondral bone.
🔄 Dual‑Tissue Regeneration: Promotes chondrocyte proliferation and matrix preservation while modulating the immune microenvironment to recruit mesenchymal stem cells and enhance osteogenesis, thereby restoring joint homeostasis.

(5) Material Development
🧪 Material: CPMP Nanozyme (CeO₂@PDA‑Mg@PTHrP‑2) – fabricated by coating CeO₂ with Mg²⁺‑doped polydopamine and immobilizing parathyroid hormone‑related peptide 2 (PTHrP‑2).
⚡ Functions:

Exhibits enzyme‑like antioxidant activity to scavenge ROS/reactive nitrogen species and generate oxygen.

Converts near‑infrared light into heat for photothermal‑controlled release of Mg²⁺ and PTHrP‑2, inducing HSP70 expression.

Demonstrates efficacy in OA models by alleviating inflammation, reducing bone resorption, and preserving cartilage integrity.

#NanoMedicine #InterdisciplinaryEngineering #CellExperiments #Nanozymes #Biomaterials #Nanomaterials #2DMaterials #ScientificPaper #JournalArticle #SCIJourna #PaperSubmission #MaterialsSciencePaper #NanoResearch #ScientificPublication #NSFCHotTopics #InnovativeInterdisciplinaryResearch #NanomaterialSynthesis

Skip the Carousel

1 2 3 4 5 6 7 8 9 10

1 week ago | [YT] | 1