WealthWise

Definium Therapeutics announced positive Phase 3 results for DT120, a single-dose LSD pill being developed for generalized anxiety disorder — its third straight successful late-stage trial, after wins in depression (June) and an earlier anxiety study (August).

In this trial, called Panorama, patients taking DT120 saw significantly greater anxiety relief than those on placebo after 12 weeks, with improvement starting as early as day two.

Side effects were mostly mild and temporary, occurring on the day of dosing, with no new safety concerns raised.

CEO Rob Barrow said the results "confirmed the unprecedented efficacy of DT120 in GAD," and the company now has four supportive studies backing what it calls a potentially best-in-class treatment.

Definium plans to meet with the FDA before year-end and aims to formally submit the drug for approval in the first half of 2027.

#DFTX #Definium #DT120 #MentalHealth #Psychedelics #ClinicalTrial

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9 hours ago | [YT] | 0

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Check out Alpha Coverage: wealthwisedca.substack.com/p/alpha-coverage-179

#ITA #USO #FCG #GLD #TLT #SPY #ICLN #QCLN #DXJ #ACHR #SPCX #OpenAI #AIQ #IsarAerospace #NVDA #ASML #RGTI #QBTS #QNT #GFS #PSQL #UBER #WRD #PONY #AEHR #INFQ #CSCO #AVGO #AMD #MRVL #ARM #Anthropic #DPRO

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3 days ago | [YT] | 2

WealthWise

Saudi Arabia's crude output plunged 1.9M bbl/day to 6.238M bbl/day in August — a 23% drop from July and the kingdom's lowest level since the 1990 Gulf War — as it reported to OPEC, per Bloomberg.

Exports fell even more sharply, from 5.1M to 3.1M bbl/day, the lowest since at least 2013, per Kpler.

Saudi Aramco had rerouted crude through the Red Sea port of Yanbu to bypass a blocked Strait of Hormuz, temporarily restoring output to roughly 80% of normal levels — but that workaround has unraveled as Houthi forces expanded attacks on Saudi energy infrastructure and Red Sea shipping.

The Houthis declared a "maritime embargo" on Saudi ports in late July and have since claimed strikes on tankers including the Encelia and Layla.

This week brought further escalation: a Tuesday Houthi missile and drone barrage set oil installations ablaze and halted operations at some facilities, though Riyadh hasn't detailed the damage or production impact.

Houthi forces also reportedly seized the strategic port city of Mocha Thursday, tightening control over approaches to the Bab el-Mandeb Strait — a critical route for Saudi exports and one of the world's most important shipping chokepoints.

#SaudiArabia #OilProduction #Houthis #OPEC #StraitOfHormuz #RedSea #OilMarkets

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4 days ago | [YT] | 1

WealthWise

Oppenheimer Analyst Edward Yang initiated Aehr Test Systems at Outperform and wrote, "Aehr's burn-in systems stress-test chips for early failures before deployment or costly packaging. We believe it is positioned for an AI-driven inflection as rising power and package value increases the cost of late failures.”

“Sonoma is already ramping with a leading hyperscaler through a record $41M order, while the more unique FOX-XP platform recently entered high-volume manufacturing (HVM) with a major AI processor, including a $22M follow-on. We model FY27/FY28 revenue of $141M/$218M, with F2Q27E above consensus on Sonoma.

“Valuation looks rich, but estimates give little credit to FOX potentially winning a second major AI processor. Even one additional leading AI processor adopting FOX in HVM could require dozens of systems and materially raise AEHR's earnings ceiling."

#AEHR #Semiconductors #AI #ChipTesting #AehrTestSystems

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4 days ago | [YT] | 0

WealthWise

Uber deepened its autonomous vehicle push across Europe this week.

WeRide, Uber, and AVOMO (Moove Cars Group's AV arm) received Spain's first national Level 4 permit from the Directorate General of Traffic, authorizing 20 supervised WeRide GXR vehicles to begin mapping and route validation across Greater Madrid ahead of a commercial launch targeted for end of 2026 — WeRide's ninth global AV permit and fourth city in its 15-city Uber partnership.

Separately, Pony.ai and Verne began fully driverless robotaxi test rides with passengers in Zagreb, Croatia — a European first — along a 22-kilometer route linking Verne's headquarters and a major business district to Franjo Tuđman Airport, with plans to expand the operating area in coming months.

Uber's leadership also bought into the stock this week: CEO Dara Khosrowshahi purchased 141,000 shares for ~$10 million ($70.73-$71.18/share) on Sept. 10, lifting his direct holdings to 1,367,100 shares; COO Andrew Macdonald bought $5.3 million (70,000 shares at $75.83) the day before — a combined $15 million in insider buying.

#UBER #WRD #WeRide #PonyAI #AVOMO #AutonomousVehicles #Spain #Zagreb

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4 days ago | [YT] | 2

WealthWise

Japan's foreign reserves fell a record $79.6B (6.18%) in August to $1.208 trillion — the fastest drop since Ministry of Finance records began in 2000, and a fourth straight monthly decline.

Foreign securities holdings, ~70% of which are U.S. Treasuries, dropped $87.8B to $839.6B — a decline nearly matching the scale of Japan's $98.66B (¥15.4T) yen-buying intervention between July 30 and Aug. 26, the largest single-month intervention on record.

The Japan Times reported Tokyo "likely sold a portion of its holdings of foreign securities, including U.S. Treasurys, to finance its record currency intervention... despite concern in Washington over the impact of Treasury sales on long-term yields."

Part of the operation was conducted jointly with the U.S. — the first coordinated intervention by the two countries since 2011 — helping lift the yen from a 40-year low near 164/dollar to as high as 155.20 before it settled around 155-156.

Combined 2026 intervention spending has reached ¥27.1 trillion, Japan's largest yearly total on record.

To ease pressure on Japan's Treasury holdings going forward, Tokyo and Washington have flagged a COVID-era Fed backstop facility for major central banks, which would let Japan raise dollar liquidity without further outright Treasury sales.

Treasury Secretary Scott Bessent has said Washington "will not hesitate" to join future joint interventions.

#Japan #Yen #Treasuries #ForexIntervention #BOJ #USDJPY #CentralBanks

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1 week ago | [YT] | 0

WealthWise

Analysts Craig Ellis and Rebecca Zamsky wrote, "We view the entity as one of just two publicly traded quantum names presenting a full-stack platform play with multiple product groups plus an optimized software stack, alongside IonQ."

Ellis said, "We like an advantaged technology position, as neutral-atom all-to-all gate connectivity lends high logical qubit efficiency and error correction to lift our confidence that already commercial sensing products can add compute systems in a few years. Because the same physics underpins sensors and clocks today and likely compute systems ahead, leverage prospects seem compelling inside a large and growing TAM, rising to $16.5 billion and $35 billion-$80 billion in 2030E and 2035E, respectively, with our CY28 and CY29 revenue estimates rising to $75 million and $90 million."

Ellis added, "Continued volatile sector share action, which often seemingly amplifies AI sentiment, is presenting attractive entry points, in our view, into a steady stream of potential 12-month fundamental and financial catalysts as the industry races toward commercial workload uptake in a few years, which we believe will eventually span all industries. While early-stage valuation is tricky and with numerous risks to navigate, we believe INFQ has the right ingredients and potential execution to be a long-term quantum winner."

#INFQ #Infleqtion #QuantumComputing #Investing #QuantumComputingStocks

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1 week ago | [YT] | 0

WealthWise

BofA strategist Michael Hartnett said 10-year rolling annualized returns on long-dated Treasuries (15+ year maturities) have fallen to negative 2% — the asset class's weakest 10-year stretch in a century, compared with 15% for U.S. equities and 11% for commodities over the same window.

He noted, "At no time in the past 90 years has 10-year rolling return from US Treasuries been negative."

Hartnett argues such decade-long troughs have historically marked lucrative entry points — citing S&P 500 bottoms in 1939, 1974, and 2009, and commodity bottoms in 1933, 2018, and 2020 — and sees Treasuries nearing a similar multi-year inflection point.

#Treasuries #Bonds #FixedIncome #MarketOutlook #Yields

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1 week ago | [YT] | 0

WealthWise

Nomura said the BOJ could raise rates at three consecutive meetings — September, October, and December — in an extreme scenario if yen weakness persists toward 160.

Head of FX strategy Japan Yujiro Goto said a quarter-point hike this month "looks reasonable”. Goto also flagged that external pressure from the U.S. could further influence BOJ decision-makers.

The BOJ last raised rates in June to a three-decade high of 1% and held in July; its September 17-18 meeting is now the focal point, with board member Hajime Takata leaving the door open to a 50bps or 75bps hike, and Governor Kazuo Ueda saying the bank needs "to pay greater attention than before to upside risks" to inflation.

USD/JPY has been testing resistance near 160.

Reuters reported three sources saying the BOJ is set to hike as soon as September and could accelerate its pace beyond the usual twice-a-year cadence, citing Middle East-driven price pressures, AI demand, and persistent yen weakness despite last month's rare joint U.S.-Japan currency intervention.

#BOJ #Yen #Japan #InterestRates #USDJPY #CentralBanks

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1 week ago | [YT] | 0

WealthWise

Samsara beat Q2 with non-GAAP EPS of $0.20 (beat by $0.04) on revenue of $508.4M (+30% Y/Y, beat by $25.1M).

CEO Sanjit Biswas said, "In Q2, we added 242 customers with $100,000 or more in ARR and 20 customers with $1 million or more in ARR. Both are quarterly records," adding, "Customer adoption of some of our latest AI features is up more than 4x in the last 2 months."

CFO Dominic Phillips said, "Non-GAAP operating margin was 21% in Q2... Free cash flow margin was 13%... and GAAP EPS was a positive $0.03, representing our fourth consecutive quarter of GAAP profitability."

Q3 guidance: adjusted EPS of $0.18-$0.19 (above the $0.18 estimate) and revenue of $514M-$516M (above the $509.7M estimate).

Samsara also raised full-year guidance to $0.76-$0.78 adjusted EPS (up from $0.70-$0.72) on revenue of $2.043B-$2.047B — both above the $0.72 EPS and $2.01B revenue analysts had expected.

#IOT #Samsara #AI #SaaS #FleetManagement #IndustrialAutomation #Automation

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1 week ago | [YT] | 2