Optispan is a vision for what health should be.
The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good.
We believe that the current practice of medicine is disease care, not health care. We believe that everyone can get closer to their own optimal healthspan.
Join us on a journey of discovery as we explore the science of longevity and optimal healthspan ("Optispan"). The journey is the reward.
We hope you find this content valuable, join by subscribing to the channel, and come back often. More importantly, we hope that you apply what you learn here to recover your lost decade, and perhaps much more.
Dr Matt Kaeberlein
What If One Blood Test Could Detect 50 Cancers?
1 week ago | [YT] | 15
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Dr Matt Kaeberlein
Galleri is a blood test that is able to detect multiple types of cancers.
It has the potential to detect up to 50 different types of cancers from a single blood draw.
A relatively noninvasive test that detects about half of existing cancers with a false positive rate of 1%, which is better than any other cancer screening method we have.
We just have to figure out how best to use it.
I personally think there's probably value in certain high-risk populations for the Galleri test right now, even though we may not have the definitive clinical trial data to prove it yet.
1 week ago | [YT] | 19
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Dr Matt Kaeberlein
I took the Galleri cancer test. Here's why.
Full disclosure: We offer Galleri in some of our programs at Optispan, but we don't recommend it for everyone.
Before we ever rolled it out, I took it myself.
I felt an obligation to try anything we use as part of our core toolkit.
In the latest podcast, I walk through my personal take on the test, the new trial data, and the tough questions you need to ask yourself before taking it:
Listen to the full episode for my honest take.
1 week ago | [YT] | 7
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Dr Matt Kaeberlein
The Galleri trial headline sounded great. The data showed a different story.
1 week ago | [YT] | 9
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Dr Matt Kaeberlein
The company that manufactures Galleri, GRAIL, released the results of an NHS trial in the UK.
So they put the press release out teasing the trial results on February 19th.
The title of that press release was 'Landmark NHS Galleri Trial demonstrates a substantial reduction in stage four cancer diagnoses, increased stage one and two detection of deadly cancers, and fourfold higher cancer detection rate.'
That sounds pretty darn good, right?
The problem is, the take-home of the story was that the trial actually failed to meet its primary endpoint, which was showing a reduction in stage four cancer.
So obviously, they did their best to put a positive spin on the story, noting the higher detection of early-stage cancers and favorable trends in late-stage cancers.
But the fact is, they missed their endpoint, and the stock proceeded to tank by about 50%.
1 week ago | [YT] | 9
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Dr Matt Kaeberlein
🚨 Is it time to abandon the Galleri multi-cancer detection test?
A few weeks ago, GRAIL released the results of their huge NHS trial, and the test failed to meet its primary endpoint.
The stock dropped ~50%. Headlines called it a failure.
But is that the whole story?
In our latest episode, we separate the signal from the noise. We unpack:
- What the NHS trial actually found (the good and the bad)
- Why a 99% specificity doesn't tell the whole story
- Who should (and shouldn't) consider taking this test
🎧 Tune in for the full breakdown.
1 week ago | [YT] | 5
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Dr Matt Kaeberlein
Even if it is just a blood draw, this is a risk you should keep in mind
1 week ago | [YT] | 2
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Dr Matt Kaeberlein
Galleri has the potential to detect up to 50 different types of cancers from a single blood draw.
You may be asking, what's the risk?
It's just a blood test, right? Not a big deal.
It is true. The test itself is not dangerous.
But the biggest risks are around false positives and false negatives.
So a false positive in this case would mean you take the test.
You don't have cancer, but you get a report back that says cancer detected. And that does happen.
Why is that a problem?
Well, it sure creates a lot of anxiety for people to be told cancer has been detected.
It leads to unnecessary follow-on diagnostics and procedures, some of which can be very invasive depending on the type of cancer that was detected.
1 week ago | [YT] | 18
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Dr Matt Kaeberlein
At this point, who do you think the GALLERY cancer test is most appropriate for?
1 week ago | [YT] | 1
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Dr Matt Kaeberlein
Here’s what actually happens to your body when estrogen drops.
2 weeks ago | [YT] | 12
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