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Reproductive • USMLE Step 2 CK @doctordc_online
A 24-year-old woman presents with irregular menses, hirsutism, and infertility. BMI is 31. Labs show elevated LH:FSH ratio and elevated free testosterone. Pelvic ultrasound shows multiple small peripheral ovarian follicles. For a patient not currently desiring pregnancy, which of the following is the most appropriate first-line management?
13 hours ago | [YT] | 6
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Biostatistics & Epidemiology- USMLE step 1 @doctordc_online
A prospective cohort study follows 500 smokers and 500 non-smokers for 10 years. 100 smokers and 25 non-smokers develop coronary artery disease. What is the relative risk of CAD in smokers versus non-smokers?
21 hours ago | [YT] | 4
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Psychiatry • USMLE Step 2 CK @doctordc_online
A 34-year-old woman reports 6 weeks of depressed mood, anhedonia, insomnia, poor concentration, and a 5-kg weight loss. She denies suicidal ideation. She has no significant past medical history. Which of the following is the most appropriate initial pharmacologic treatment?
1 day ago | [YT] | 2
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Biostatistics & Epidemiology- USMLE step 1 @doctordc_online
A case-control study examines the association between NSAID use and peptic ulcer disease:
Cases (ulcer) Controls (no ulcer)
NSAID exposed 120 60
NSAID unexposed 80 140
1 day ago | [YT] | 3
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Neurology • USMLE Step 1 @doctordc_online
A 70-year-old right-handed man suddenly develops right-sided face and arm weakness greater than leg weakness, along with an inability to speak fluently despite intact comprehension. Which vessel occlusion best explains this presentation, and where is the causative lesion located?
2 days ago | [YT] | 4
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Biostatistics & Epidemiology- USMLE step 1 @doctordc_online
An observational study finds a strong association between coffee consumption and pancreatic cancer. Critics point out that heavy coffee drinkers are also more likely to smoke, and smoking is an independent risk factor for pancreatic cancer. Which approach would best address this problem in the analysis?
2 days ago | [YT] | 2
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Hematology/Oncology • USMLE Step 1 @doctordc_online
A 30-year-old woman has microcytic, hypochromic anemia with an elevated red cell distribution width (RDW). Serum ferritin is low and total iron-binding capacity is high. Which of the following additional findings would best distinguish this diagnosis from beta-thalassemia trait?
3 days ago | [YT] | 6
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Biostatistics & Epidemiology - USMLE Step1 @doctordc_online
A new screening test for pancreatic cancer detects tumors on average 18 months earlier than clinical symptoms would. In a screening trial, screen-detected patients have a 5-year survival of 40%, versus 15% in symptom-detected patients — but overall mortality from pancreatic cancer in the screened population is unchanged. What best explains this discrepancy?
3 days ago | [YT] | 3
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Biostatistics & Epidemiology- USMLE Step1 @doctordc_online
A 4th-generation HIV antigen/antibody test is studied in 2,000 patients:
HIV + HIV − Total
Test + 95 19 114
Test − 5 1881 1886
Total 100 1900 2000
What is the negative predictive value of this test?
4 days ago | [YT] | 2
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Endocrine • USMLE Step 1 @doctordc_online
A 19-year-old woman with type 1 diabetes presents with Kussmaul breathing, fruity breath odor, and abdominal pain. Labs show glucose 480 mg/dL, arterial pH 7.15, and positive serum ketones. Which of the following best explains why ketoacidosis develops in this patient but is rare in patients with type 2 diabetes presenting with similarly high glucose levels?
4 days ago | [YT] | 9
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