Genefitletics

From today, we are starting a “demystifying health” series.

Twice, every week we will share precision insights related to precision nutrition, its interaction with microbiome & how microbial & cellular functions are programming our biology for either health or disease

These insights are not fiction, self belief, unsubstantiated claims or anecdotal evidence but derived from molecular data, we at Genefitletics have collected & analysed over the last 6 years.

Yeah, we have built & commercialised a precision medicine platform that gives a digital footprint of human biology at cellular level & disease modifiable interventions based on cellular & molecular data not irrelevant healthcare delivery(POC diagnostic & wearables) data.

The first & important aspect of nutrition which we are going to discuss today is “Coffee”

We all have heard both good & bad things about coffee with some people claim that coffee is beneficial while others may say it causes high blood sugar, high cholesterol or it should not be consumed in afternoon & beyond

Coffee has both both beneficial & harmful effects depending upon its interaction with your microbiome

Swipe the images to know more

If you really want to fix your biology to the core, we are your best bet. We are the only company in India that measures your cellular functions in order to identify what specific food substrates would stimulate beneficial functions which should be minimised or avoided right now.

More details here: www.genefitletics.com/orahyg

#gutmicrobiome #gutmicrobiometest #gutbrainaxis #guthealth #nutritiontips #health #healthtips #healthyfood #coffee #coffeelover #coffeeaddict #coffeetime #polyphenols #oralhealth #oralmicrobiome #oralmicrobiometest #oralhygiene #oralcare #dentist #dentistry #dementia #dementiasupport #cognitivedecline #cognitivehealth #mentalhealthmatters #mentalhealth #mentalhealthawareness

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5 months ago | [YT] | 0

Genefitletics

Brace up folks, this is revolution we have been working on for last 6 years, 

No theory, no science fiction- just real molecular data(biochemistry) from our customers & pure mathematics

With 25 billion nucleotides sequenced & 20 billion molecular data collected, mined, analysed & interpreted, we have build a machine learnt model & cracked the code to detect cardiovascular disease at stage 0-1

No irrelevant tracking of blood pressure, homocysteine, HDL, LDL or crp levels!

We have looked, analysed & combined cellular functions & gut + oral molecular pathways causing loss of elasticity of blood vessels, oxidative stress, platelet aggregation plaque deposition, instability & rupture & arteries blockage to detect CVD at an earliest stage

Now we are applying this detection model, with specificity of 85% & sensitivity of 98%, & overlaying the algorithm on molecular data of every customer to detect the onset of CVD 10 years before clinical symptoms appear in routine diagnostic tests

Our recommendation engine then constructs & delivers nutritional therapeutics that modulate & inhibit disease promoting pathways to prevent onset of CVD, stop its progression or outrightly reverse them.

Your healthcare practitioners can have access to these molecular insights, not identifiable by routine diagnostic investigations, to personalise their treatment &  can blend it with nutritional therapeutics to close the gap in patient care.

The solution is available at scale right here right now

Know more about how you can prevent the onset & progression of cardiovascular disease here:

www.genefitletics.com/cardiovascular-disease

#heartdisease #heartattack #heartdiseaseawareness #hearthealth #metabolichealth #type2diabetes #coronaryarterydisease #cardiology #cardiologist #highbloodpressure #lowbloodpressure #hypertensionawareness #hypertension #cardiovasculardisease#heartcondition #healthhack #heartpalpitations #heartconditions #cholesterol #lowcarbdiet #lowcholesterol #highcholesterol #statin #healthtips #heartpatients #heartsurgerysurvivor

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6 months ago (edited) | [YT] | 0

Genefitletics

Do we really have solutions to prevent & address cardiovascular diseases, the number one killer for men & women worldwide?

Oh Yeah, we could track blood pressure levels & high cholesterol levels!

Yeah our healthcare practitioners & no-science no tech healthtech companies are leveraging standard of care diagnostic investigations & some wearable stuff to track blood pressure levels but is it really helping?

No wonder , the number of Indians losing their life to cardiovascular disease stands at 272 individuals per 1,00,000 population, way more than the global average of 235 per 1,00,000 population.

Over the last few years, we have seen one of the relevant biomarker- homocysteine levels being evaluated by healthcare practitioners which gives a clear indication of the state of heart health but again the interventions based on this biomarker lacks efficacy & precision!

What exactly is homocysteine?

It is a non essential sulfur containing amino acid. Your gut bacteria could sense methionine in various foods & express a particular gene that codes for protein that metabolize & synthesize methionine and homocysteine levels. If you are consuming high amounts of this amino acid or you lack certain enzymes that can metabolize methionine in the small intestine, it could land up in your gut & specific microbes could secrete homocysteine.

However this should not be a problem since, homocysteine could be recycled back into cystathionine by cystathionine synthase which needs vitamin B 6 as a cofactor or into methionine which needs methionine synthase which needs Vitamin B12 a cofactor

But again you need help from your gut microbiome to synthesise these B vitamins. Unfortunately none of healthcare practitioners focus of balancing gut microbiome as a part of their treatment protocol

If your gut microbiome cannot produce these cofactors, it could lead to high level of homocysteine

High homocysteine leads to overexpression of Asymmetric dimethyl arginine(ADMA) which suppresses nitric oxide(NO) production. Since NO & is a vasodilator, dilates blood vessels & regulates blood flow, functional loss of NO could trigger onset of cardiovascular disease

If you really want to fix your cardiovascular health, focus on promoting gut microbial beneficial functions & eliminating instances of gut dysbiosis.

www.youtube.com/shorts/ZMwLYF...

We at Genefitletics measure & quantify your gut & oral microbiome functions to predict the onset of cardiovascular disease & provide interventions that can suppress proinflammatory activities & promote beneficial activities to improve your cardiovascular health. More details here: www.genefitletics.com/orahyg



Citations
www.pnas.org/doi/10.1073/pnas.0607965104
pubmed.ncbi.nlm.nih.gov/11714652/

11 months ago | [YT] | 1

Genefitletics

Human biology is the most  complex machinery & three major factors program our biology for health or disease. Without understanding & measuring each of these aspects, any such fad diets or coach led weight loss models leaves huge blank space.

-Our biology is as unique as our fingerprint, necessitating our unique responses to various external factors.
-Our biology is sack of tens of thousands of biochemical reactions which works in synchrony to keep our body in homeostasis.
-99% of our biology & these biochemical reactions are governed by our microbiome that constitute 99% of genes expressed inside our body & > 50% of cellular ecosystem.

If people will do well enough to read scientific journals backed by research  & empirical evidence, they would find it hard to avoid the role of microbiome in healthy weight management. Unfortunately, current weight loss solutions are nothing but a financial model with non-scientific interventions.

We have all the scientific literature & evidence in place that establishes the deep rooted connection between inflammation & weight gain. Please read them & become scientifically aware rather than falling for claims made by these fitness influencers & weight loss companies.

Link to complete blog: genefitletics.com/2024/11/04/we-are-not-obese-we-a…

We at Genefitletics, are India’s first biotech company that collects & analyzes your molecular data to measure each of these biochemical functions to construct data driven nutrition interventions that regulates your glycemic response. We have built a machine learnt model that predicts insulin response to 300 plus foods based on functional activity of your gut & oral microbiome.

Know more about us here: genefitletics.com/orahyg

#obesity #nutrition #unhealthyfood #healthyfood #healthylifestyle #healthcare #healthcoaches #health #nutritiontips #nutritiontips✔️ #diabetestipo2 #lossweight #obesity #obesityfreeindia #obesityfreenation

1 year ago | [YT] | 0

Genefitletics

Like many life threatening chronic diseases, the molecular mechanism behind onset of cancer has not been understood.

The current practice focuses on somatic mutation theory & considers cancer as a genetic disease & blames genetic mutation as a reason for cancer onset.

Million of dollars has been spent on understanding the genetic mutations behind cancer onset while there has been a 75% increase in the number of cancer cases.

Clearly, the current healthcare system is focussing on the wrong target. This is further reinforced by recent research which found that

- Out of 210 cancer cases sequenced, 73( 1/3rd) had ZERO genetic mutations
-Driver mutations were found in normal non-cancerous tissues while we have been always told that driver mutations are responsible for majority
-There exist genetic heterogeneity in different organs in same patients, underscoring the fact that most targeted therapies fail to treat cancer or atleast target some specific mutation in a particular organ.

If cancer is not the outcome of genetic mutations, then what causes cancer?

-How do cancer cells proliferate & grow?
-Why do personalized therapies fail in the majority of cases?
-Can personalized therapies be the reason for cancer cells to grow?
-How cancer cells metastasise?
-How can we starve cancer cells?

We are sure these are frequent questions which come in mind of people who have lost their family/friends to cancer or have seen them suffering while dealing with this dreaded disease.

In order to demystify this & spread knowledge & awareness about the mechanism behind cancer onset, we are doing a webinar on 18th Oct '2024 at 1800 Hrs.

We are sure you do not want to miss this.

Register for the event here: lnkd.in/gebV8eNU

1 year ago | [YT] | 0

Genefitletics

Cancer has been regarded as a genetic disease caused by genetic mutations driven by somatic mutation theory.

You would be have influx of number of DNA testing or early cancer detection companies claiming they could detect risk/early cancer onset looking at certain genetic mutations, circulating tumour cells or physical examinations

These all are driven by a financial model to make money out of personalized chemo/immuno or radiation therapies irrespective of success of such therapies throwing toxins inside our body.

It has now been found that somatic mutation theory(SMT) is a flawed approach & cancer is a mitochondrial metabolic disease(MMT). In a recent research it was discovered there was absence of genes mutations & chromosomal abnormalities in 73 out of 210 cancer cases by sequencing their biological samples(1) while driver gene mutations, said to be responsible for a number of cancers, was found in normal cells which are non cancerous (2).

It has also been found that there exists genomic heterogeneity in different tumor cells which itself makes these targeted therapies sub-optimal & genetic mutations can easily bypass them.

So what causes Cancer ? It is damaged respiration( mitochondria dysfunction) followed by compensatory fermentation(4).

Yes it is mitochondria dysfunction caused by chronic inflammation, carcinogenic toxins, viruses, environmental toxins & more which shuts down the kill switch that controls cell cycle. This leads to cell growth & proliferation triggered by ancient fermentation pathways that ferments glucose & glutamine(3).

In order to break this myth that cancer is a genetic disease & understand the molecular mechanism behind cancer onset, we have started “Prevent Cancer Podcast”

The first episode : What causes cancer ? is live now.

Watch here: https://www.youtube.com/watch?v=OOReA...

Listen on Spotify: podcasters.spotify.com/pod/show/genefitletics/epis…

Also available on Apple Podcast & Amazon Music

Citations

(1) www.ncbi.nlm.nih.gov/pmc/articles/PMC2712719/
(2) pubmed.ncbi.nlm.nih.gov/30467157/
(3)www.ncbi.nlm.nih.gov/pmc/articles/PMC4493566/
(4) www.ncbi.nlm.nih.gov/pmc/articles/PMC8467939/

#cancerawareness #cancermedicine #cancerprevention #cancerresearch #chemotherapy #chemotherapie #chemosideeffects #chemotherapysideeffects #cancersurvivor #cancerpatients #cancerpatient #oncology #oncologia #radiationtherapy #radiationoncology #radiationoncologist #cancergenes #dna #genetesting #dnatest #dnadiet #microbiome #cancertest #earlydetectionsaveslives #earlydetection #oralmicrobiome #gutmicrobiome #gutmicrobiometest #oralmicrobiometest #nutritionfacts #nutritiontips #cancerdiet #geneticmutation #healthpodcast #cancerpodcast

1 year ago | [YT] | 0