Dr. Rege

No video this weekend.
I’m deep in the edit for the next release - an analysis of the film Aftersun.

This one isn’t a “movie review”.

It’s a slow, careful exploration of what the film does to you ( and your emotional world) without ever spelling it out.

Think:

- memory as fragments, not a story

-the gap between what a child sees and what an adult later understands

-love expressed through routines… while something unspoken sits underneath

-the quiet weight of masculinity, mood, and connection

I’m taking my time with this because if you’ve seen Aftersun, you know it deserves that.

I want it to be impactful — not rushed.

Back soon.

2 days ago | [YT] | 38

Dr. Rege

“It’s not ADHD, it’s trauma.” 🚨

You’ve probably heard that line – often linked to Gabor Maté – and it’s everywhere in ADHD discussions right now.

In my new video, I unpack where that idea is helpful, where it quietly becomes unsafe, and what the neuroscience actually shows when you look at ADHD and trauma through circuits, development, and allostatic load rather than slogans.

The aim isn’t to dismiss Maté, but to show why “it’s all trauma” can miss real neurodevelopmental conditions – and why the integration of both matters for patients.

I’m curious: in your experience (clinical or lived), have you seen ADHD dismissed as “just trauma”?
Watch here 👇

1 week ago | [YT] | 45

Dr. Rege

Treatment resistant or Treatment without direction? 🚨🤔

We often change doses, switch medications, or try a new therapy without ever spelling out what “better” is supposed to look like in real life.

In this new video, I walk through 3 questions that can:

1. Help you and your clinician define what improvement actually looks like

2. Turn “I don’t feel better” into clear, trackable changes in daily life

3. Link emotions (sad, angry, anxious, numb) back to what you might need next

It’s for patients, families, and clinicians who are tired of random trial-and-error and want a clearer map for recovery.

🎥 Watch the video here 👇

2 weeks ago | [YT] | 11

Dr. Rege

🚨We keep telling people to “exercise”… but for many, that advice quietly makes things worse.

The real lever for mental health isn’t exercise — it’s movement, prescribed the right way, matched to the phase of recovery.

In this new video, I break down:
• why motivation comes after action
• the brain pathways that actually help people get started
• a simple movement script you can use today (clinicians + patients)

If you’ve ever wondered why your patients — or you — can’t “just exercise,” this will make immediate sense.

#exercise #drrege #neuroscience

2 weeks ago | [YT] | 62

Dr. Rege

🧠 Your brain isn’t built for stimulation — it’s built for balance. 🚨

So why do some people on stimulants keep needing more — higher doses, shorter relief, faster burnout?

Sometimes the crash isn’t a sign of “tolerance”… it’s your brain pulling the brakes to protect itself.

In this video, I explain why increasing the dose can paradoxically make stimulants work less,
and how to find the Goldilocks zone — where focus meets stability.

Let me know your experiences with stimulants and dose responses in the comments below.

#Dopamine #ADHD #MentalHealth #DrSanilRege #PsychiatrySimplified #PsychScene

3 weeks ago | [YT] | 15

Dr. Rege

🧠 What was the brain really built for?
(Hint: it’s not to make you happy.) 🚨

Most of us grow up believing mood = how we feel.

But what if mood is actually the brain doing something far stranger…

Something evolution cared about far more than happiness?

In the new video, I break down a neurobiological idea that completely flips the concept of mood on its head and once you see it, you’ll understand yourself (and others) very differently.

A small warning: ⚠️

This will change the way you think about low mood, motivation, effort, and even why life feels “off” sometimes…
but in a way that finally makes sense.

If you’ve ever wondered:
“Why do I feel low even when nothing is wrong?”
or
“Why doesn’t happiness last?”
— this explanation will connect dots you didn’t know were related.

I won’t spoil the core idea here, but it’s grounded in dopamine, prediction, and the brain’s ancient survival machinery…
and it reveals why happiness is a side-effect, not the target.

🎥 New video out now — watch it and then tell me:Does this shift how you understand your own mood?
👇 Share your thoughts in the comments. I’d ❤️to hear what you think.

3 weeks ago | [YT] | 30

Dr. Rege

New video is live 🎥

I’ve just released a breakdown of Modafinil vs Armodafinil – what they actually do in the brain, where they genuinely help, and why they’re not the “limitless smart drugs” they’re often sold as.

In this video I cover:

1. How Modafinil & Armodafinil work on dopamine, norepinephrine, orexin & histamine

2. The real clinical roles in narcolepsy, shift work, sleep apnoea, depression & ADHD

3. The idea of “performance debt” – perform now, pay later

4. Side effects, rare risks, and whether healthy people should be taking them at all

If you’re a clinician, a science-curious viewer, or someone considering these meds, this one’s for you.

1 month ago | [YT] | 9

Dr. Rege

PCOS in Psychiatric Practice 🚨

PCOS isn’t only a syndrome of relevance in endocrinology - it’s a neuroendocrine condition with major psychiatric implications.

PCOS disrupts the HPG axis → ↑ LH:FSH ratio → impaired follicle maturation → hyperandrogenism & altered neurosteroid pathways.

Why it matters for psychiatry 👇

📊 56.9% of women with PCOS have at least one psychiatric disorder

Common associations:

-Depression & anxiety
-Bipolar disorder
-Schizophrenia spectrum presentations
-Eating disorders
-OCD & personality vulnerability patterns
-Sleep disorders

Emerging links:

- PCOS & ADHD - altered neurosteroid signalling and dopamine pathways may contribute

- Maternal PCOS → increased ADHD risk in offspring, particularly boys

- Higher risk of new-onset sleep disorders - metabolic + circadian disruption

Clinical insights 💡

👉PCOS affects neurotransmission, inflammatory pathways, metabolism, and neurosteroids shaping cognition, mood, and stress responsivity.

👉Integrating reproductive endocrinology into psychiatric assessment improves diagnosis and treatment planning.

For a cpsychscenehub.com/psychinsights/female-specific-ps… understanding of female psychiatry and psychopharmacology 👉

1 month ago | [YT] | 37

Dr. Rege

New Video Released: When Pain Becomes a Memory of Threat 🚨

Chronic pain is often treated as a tissue problem.
But chronic pain reflects a brain state👉 one of ongoing threat.

In this new video, I explore why pain can persist after healing, and how the brain’s prediction and safety systems shape the experience of pain.

We cover:

• Pain vs nociception
• Central sensitisation & neuroinflammation
• Failure of descending inhibition
• Pain as a predictive brain state (“I am unsafe”)
• How early experiences and emotional learning shape pain response
• The PACES™ domains in chronic pain
• Why medication alone lowers intensity but rarely resolves pain
• How trust, safety, connection, and pacing drive neuroplastic change

If you manage chronic pain clinically — or live with it — this framework may help you think differently about treatment and recovery.

Thank you for being part of this learning community — stay curious.


Dr Rege

#MECFS #Fibromyalgia #LongCovid #POTS #ChronicPain
#Dysautonomia #Neurobiology #Neuroinflammation
#CentralSensitization #NervousSystem #BrainHealth
#SafetySignalsNotWeakness #TraumaAndHealing
#PredictionError #ChronicIllnessSupport #PsychiatrySimplified
#Neuropsychiatry #DrRege #PsychScene

1 month ago | [YT] | 24

Dr. Rege

Neurosteroids, Mood Regulation, and Women’s Mental Health 🚨

Neuroactive steroid balance is a core , yet often under-recognised driver of mood, cognition, and sexual function in women's mental health.

1️⃣Key circuits modulated by neurosteroids:

1. PFC → executive function, planning, cognitive resilience

2. Amygdala → affective regulation, irritability, anxiety reactivity

3. Hippocampus → memory, learning, stress buffering

4. Nucleus accumbens → reward processing, motivation

5. Hypothalamus → sleep, appetite, libido, thermoregulation

2️⃣Clinical manifestations of neurosteroid dysfunction :

1. PMDD: cyclical affective instability, irritability, cognitive fog

2. Perimenopausal depression: mood variability, anxiety, cognitive decline

3. Menopause: anhedonia, sexual dysfunction, sleep & vasomotor disruption

These conditions sit at the intersection of neurosteroid changes , GABAergic modulation, neuroinflammation, and neural circuit plasticity.

3️⃣Clinical insights : 💡
Assessment and treatment planning should integrate:

👉Reproductive stage
👉Neuroendocrine context
👉Symptom timing & patterns
👉Cognitive and affective changes
👉Sexual health and somatic Sx

Psychiatrists play an imp role in bridging psychopharmacology, hormonal understanding, and psychological support in these presentations.

YT videos 👉Women's Mental Health
www.youtube.com/playlist?list...

For clinicians 👉Learn more via The Academy by Psych Scene 👉Women’s Mental Health Program with experts Prof Jayashri Kulkarni & Dr Ceri Cashell

1 month ago | [YT] | 44