PoorMansChemist

I was at work when all of the cameras on the front porch started sending me notifications that there was motion by my front door. At least I got some high def pics of the burglar. 😀😀

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2 days ago | [YT] | 30

PoorMansChemist

I had to restrict access to the Gemini notebooks. I'm sorry guys but apparently people were asking some pretty naughty questions because I started getting warnings from Gemini about "assisting illegal activity". You have to be pretty unsubtle for it to start saying stuff like that so I can only imagine what people were asking it. However, I think everyone was able to see the utility of these Gemini notebooks (some perhaps a little too much) so the point I wanted to get across was made. You don't need a paid account to use Gemini or create your own notebooks and the zlibrary is a thing. So you don't need to pay for the books or journal articles either. All you need are a Google and a zlibrary account and some patience (zlibrary only lets you download 10 things a day on a free account). So go forth and make your own awesome AI science assistants. :-)

4 days ago (edited) | [YT] | 34

PoorMansChemist

Anyone recognize this little guy? He seemed hell bent on getting himself killed this morning. Took me *forever* to get him to move to a safe spot!!

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1 week ago | [YT] | 28

PoorMansChemist

Important Safety Tip: So I discovered something new tonight that I think many of you would be keen to know. Apparently my assumption that "the larger the substituent on the tryptamine amine nitrogen the less physiologically active the compound" is only partially correct. It holds for aliphatic substituents. By the time you get to N,N-dihexyltryptamine the compound is more or less inert and anything larger than that makes it even more so.

However, this is *not* true of benzyl substituents!! Monosubstituting that amine nitrogen with a benzyl substituent creates a compound with vastly increased 5HT2A binding affinity!! Apparently there is some kind of lipophilic side pocket on the 5HT2A receptor binding site that perfectly fits a planar benzene ring! So when I said that reducing the Schiff bases we made would make a compound with no hallucinogenic activity I was incorrect. But dont stop reading here and run off to your labs because there a MASSIVE caveat to this!

So first off tryptamine doesnt work well for making these N-benzyltryptamines since the compounds it makes are less potent partial agonists but 5-methoxytryptamine works very well for it. The benzyl substituent will yield extremely potent compounds if it is substituted at the meta position with a methoxy group, methylthio group, or a halogen like bromine or iodine. Substitution at the ortho position yields moderately more potent compounds and substitution at the para position kills the activity.

The caveat I mentioned earlier is this: most of the compounds I've described are full agonists at the 5HT2A receptor. All of the classic psychedelics are partial agonists. Some of them apparently also lack high binding specificity and they will bind to 5HT2C receptor is as well. This means that they potentially have the exact same problems as the NBOMe compounds. They could very well be (and to some extent probably are) trippy heart attack powder. They also essentially have no history of human use meaning making one of these things and taking it is chemical Russian roulette. Even if it doesn't kill somebody the first time that's not proof that it's safe. So please don't get any clever ideas.

2 weeks ago | [YT] | 57

PoorMansChemist

Does anyone know what kind of beetle this is (location was Greenville, SC, USA)? Never seen one like it before. I was walking through the warehouse at work the other night and little dude was sitting on the floor! I moved him so he wouldn't get run over by a forklift. This little guy looks EXACTLY like a piece of wood! The camouflage is amazing!!

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3 weeks ago | [YT] | 26

PoorMansChemist

Left to right: N-(salicylidene)tryptimine complexes of europium, terbium, vanadyl, and uranyl cations.

3 weeks ago | [YT] | 56

PoorMansChemist

So for some reason this stuff spontaneously changed the color of its fluorescence from bright yellow green to a kind of orange color! it started happening in one small patch and I thought that it was contamination with some kind of metal on the glass. But I couldnt get it to go away by normal means. So I recrystallized all of it from boiling ethanol and now it's fluorescence isn't quite as bright but it's a much more solid yellow. however as it's exposed to UV the fluorescence dens and the solid changes to a kind of orange color. it seems to recrystallize normally though. I'm not sure if it's breaking down although that would be logical.

3 weeks ago | [YT] | 43

PoorMansChemist

We need more channels like this!
https://www.youtube.com/watch?v=_RinD...

4 weeks ago | [YT] | 15

PoorMansChemist

On the left we have bis(N-(salicylidene)-5-methoxytryptimine)copper(II) and on the right we have bis(N-(salicylidene)-5-methoxytryptimine)palladium(II). I only bought five grams of 5-methoxytryptamine so its all been used up on these two compounds. But thats a-ok!! Weve made a beautifully colored, exotic compound from hallucinogen precursors and precious metals!! Thats evereything this channel is about!! 🥰🥰🥰

PS Even more sincere thanks to the Mysterious Benefactor for supplying the palladium all those years ago! We are still making good use of it!! 🥰

1 month ago | [YT] | 64

PoorMansChemist

bis[N-(salicylidene)-5-methoxytryptimine]palladium(II). This one turned out exactly as Gemini predicted. Its amazing what AI can do when its used for good instead of evil. Also when its used correctly.

1 month ago (edited) | [YT] | 46