PoorMansChemist

I have new information that I am highly confident in because I've just confirmed it by experimentation. The last 15 hours has cleared up much confusion. I can report that suboxone completely stops withdrawal from 7OH without causing precipitated withdrawal. Apparently because 7OH is only a partial agonist that has less activation potential than buprenorphine. So even if you're eating over 1 gram of 7OH every day you can start suboxone within 6 hours of the last dose with no ill effects. 32 milligrams over the course of 4 hours followed by another 8 milligrams of bupe 6 hours after that was all it took to completely stop 7OH withdrawal.

What is fascinating is how incredibly intense the withdrawal from 7OH is. I think it is down to the incredibly short half life of 7OH (about 2 hours, on par with fentanyl and other short acting opioids) and the vast amounts of it you can consume without dying (or indeed any real ill effects that I saw) once you're habituated to it. The reason bupe can cover 7OH withdrawal is due to its much, much higher binding affinity and greater activation of the receptor. What blows me away more than anything is that something as weakly binding and weakly activating as 7OH can cause such an intense, nightmare-fuel withdrawal. I was going to try to get through 12 hours of it and then start the bupe just to be sure no precipitated withdrawal happened and I couldn't do it. I got through about 10 minutes before I cracked. Gemini told me enough about the binding affinities and activation potentials that I figured it was worth the risk. Happily there was never any need to worry.

I will make a video about all of this soon. I want to help people get off 7OH with as few consequences as possible. If you're using fentanyl, however, you're fucked. None of this applies to you. Fentanyl is too strongly binding and too strongly activating for even 32 mg of bupe to be enough. And most fentanyl is cut with xylazine with causes an opioid-like withdrawal but by a completely different mechanism (it is an alpha 2-adrenergic receptor agonist not a mu receptor agonist) and no good drugs exists to treat xylazine withdrawal. Not like with opioid withdrawal. You're just on your own with that one. Don't use street fentanyl kids. There is no road out from it that doesn't go through hell. 7OH, however, truly is the most forgiving mu agonist known to human science when it comes to physical dependence treatment. The road out of that bypasses hell entirely.

1 day ago (edited) | [YT] | 65

PoorMansChemist

New toy acquired! 🥰 Thank you Mysterious Benefactors!!

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5 days ago | [YT] | 72

PoorMansChemist

Thank you to everyone who mentioned the instability of aniline on the previous post! I have never worked with it before and so was unfamiliar with its reputation as being a reagent that doesn't keep well on the shelf. Given everything you've told me I am glad I didn't open it yet!!! I figure I will come up with a detailed plan first and then open it up and expose it to air. Until then it can hang out in my lab where there is little risk of it being exposed to all of the various things that make it unhappy. Which seems to be everything. It seems to have some kind of grudge against being brought into existence. Not explosive levels of grudge although if you told me it could blow up somehow it wouldn't surprise me. Probably makes some weird oxygen-nitrogen hellspawn that's barely held together by resonance whose vapors cause raging butthole cancer and which explodes into fire if you look at it funny.

2 weeks ago (edited) | [YT] | 66

PoorMansChemist

The aniline arrived today! That was fast! I think it was less than 48 hours from when I place the order to when I received the package. 😲

2 weeks ago | [YT] | 89

PoorMansChemist

YouTube has started hiding replies to comments now so we can't even have conversations about substituted nitrostyrenes!! This is getting utterly ridiculous! We HAVE to come up with an alternative where we can have free and open conversations about this and other chemistry topics!

I am SERIOUSLY considering shifting a lot of my focus to Patreon and Subscribe Star because 1) I can post videos there that are free for people to view just like they are on YouTube 2) you guys might actually use these sites (especially Patreon) since it's like pulling teeth to get you guys to watch the videos on BitChute, Odysee, or any other alternative platform 3) we can have free and open discussions without comments getting hidden, deleted, or otherwise interfered with!!!

Are you guys OK with that? We have to do SOMETHING because YouTube is becoming increasingly more hostile to people like us. I for one am sick to death of my videos getting shadow banned. And I am NOT paying for YouTube premium!!! I refuse to pay to use a platform that I make expensive as hell videos on for free!!!!

2 weeks ago (edited) | [YT] | 66

PoorMansChemist

I just ordered 100 mL of aniline so we can do the prep of diacetoxyiodobenzene. That is the mild oxidizing reagent used to make 7OH from mitragynine in the lab. Obviously we aren't making it for that reason. This is purely for educational purposes only. Besides this is a highly versatile and useful oxidizer in organic synthesis and so there are many different compounds it could be used to make. Although in our case we are making it just to make it. It looks like a fun prep to do. We first have to make iodobenzene from aniline. Then in a second step we convert that to diacetoxyiodobenzene. I still have to figure out how we are going to create the peracetic acid that we need for the second step of the prep. Gemini is saying that the reaction between glacial acetic and and 35% H2O2 takes 24 to 48 hours to reach equilibrium. I'm sure I'll figure out something. Do any of you guys have any thoughts about that? Has anyone out there made peracetic acid before?

2 weeks ago | [YT] | 58

PoorMansChemist

Calling all chem peeps! I need some help trying to solve a chemistry problem. I am trying to figure out if the method we used to make the 3,4,5-beta-nitrostyrene (nitromethane and cyclohexylamine in glacial acetic acid) will work to make 2,5-dimethoxy-beta-nitrostyrene from 2,5-dimethoxybenzaldehyde. If so I'd like to do a video demonstrating the reaction. But I am not going to use expensive and hard to replace reagents like nitromethane on a synthesis unless I'm reasonably confident that it's going to work. What do you guys think? Will it work?

2 weeks ago | [YT] | 13

PoorMansChemist

New video is up!! Sorry I had to turn off the comments on this one guys but I had serious concerns that people would act extra retarded on a video like this. And I just didn't want to have to fucking deal with that bullshit. Obviously it's only a few assholes in a group of otherwise mature adults. But still I had to cover my ass because I REALLY don't want this video to cause me problems later down the line! Anyways I hope you guys liked the video. I'd been saving it for a rainy day and yesterday definitely qualified as one of those! :-)

PS I am going to start uploading all the videos to Patreon and SubscribeStar (publicly; no charge to view) as well as YouTube from now on because YouTube is rapidly becoming hostile to anyone who refuses to pay for YouTube premium. I'm not paying to use a platform that I publish content on for free. So I want to start setting up viable alternatives that people might actually use.

https://www.youtube.com/watch?v=7oH9R...

2 weeks ago (edited) | [YT] | 12

PoorMansChemist

Prep complete including the final recrystallization. Working on editing the video now. Probably won't finish it tonight but I will do my best to get it done before I go to work tomorrow afternoon. Fingers crossed!

2 weeks ago | [YT] | 75

PoorMansChemist

I came up with a prep that I could do indoors. I think you guys will like this one. Stay tuned!!

2 weeks ago | [YT] | 59